80307-12-6

Basic information

• Product Name: GMBS
• Synonyms: CIVENTICHEM CV-2656;GAMMA-MALEIMIDOBUTYRIC ACID N-HYDROXYSUCCINIMIDE ESTER;GMBS;4-MALEIMIDOBUTYRIC ACID N-SUCCINIMIDYL ESTER;N-(4-MALEIMIDOBUTYRYLOXY)SUCCINIMIDE;N-Y-MALEIMIDOBUTYRYLOXYSUCCINIMIDE ESTER;N-SUCCINIMIDYL 4-MALEIMIDOBUTYRATE;N-MALEIMIDOBUTYRYLOXYSUCCINIMIDE ESTER
• CAS NO: 80307-12-6
• Molecular Formula: C₁₂H₁₂N₂O₆
• Molecular Weight: 280.23
• EINECS: 1533716-785-6
• Product Categories: Maleimide Derivatives;N-Substituted Maleimides;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;Heterobifunctional Crosslinker;heteroXlink
• Mol File: 80307-12-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 123-129 °C
• Boiling Point: 461.3°Cat760mmHg
• Flash Point: 232.8°C
• Appearance: /powder
• Density: 1.49g/cm³
• Vapor Pressure: 1.08E-08mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• Solubility: chloroform: 100 mg/mL
• PKA: -2.27±0.20(Predicted)
• Stability: Hygroscopic, Moisture Sensitive
• BRN: 6427689
• CAS DataBase Reference: GMBS(CAS DataBase Reference)
• NIST Chemistry Reference: GMBS(80307-12-6)
• EPA Substance Registry System: GMBS(80307-12-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 80307-12-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 80307-12-6 differently. You can refer to the following data:
1. A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent. Introduces maleimide groups into IgM
2. A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Useful in enzyme immunoassays

InChI:InChI=1/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2

Upstream product

• 108-31-6 maleic anhydride 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 56-12-2 4-amino-n-butyric acid 
• 15938-22-4 C₈H₁₁NO₅ 
• 116965-29-8 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl chloride 
• 57078-98-5 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid 

Downstream Products

• 1049812-36-3 C₄₆H₄₅ClN₈O₉ 

Relevant articles and documents

Synthesis of desmosine-BSA/KLH conjugates via Sonogashira/Negishi cross-coupling reactions

Desmosine is an elastin crosslinking amino acid that is expected to be a useful biomarker of diseases related to elastin degradation including chronic obstructive pulmonary disease (COPD). In this study, conjugates of desmosine and carrier proteins, such

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS

Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.