Welcome to LookChem.com Sign In|Join Free
  • or
5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione is a thiazolidinedione analogue, which is a class of compounds known for their diverse applications in the pharmaceutical industry. This specific compound is characterized by its unique chemical structure, which includes a 3-chloro-4-(2-cyclohexylethoxy)phenyl group attached to a methylene bridge, and a 2,4-thiazolidinedione ring. Its molecular composition and structural features contribute to its potential applications in various fields.

1239610-72-0

Post Buying Request

1239610-72-0 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1239610-72-0 Usage

Uses

Used in Pharmaceutical Industry:
5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione is used as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor for its potential role in modulating the inflammatory response. By inhibiting the enzyme 15-PGDH, 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione may help regulate the levels of prostaglandins, which are involved in various physiological processes, including inflammation and pain.
Additionally, 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]Methylene]-2,4-thiazolidinedione is used as a wound healing promoter, which can be beneficial in the treatment of various skin conditions and injuries. Its ability to promote wound healing may be attributed to its potential effects on cell proliferation, migration, and differentiation, as well as its possible influence on the production of growth factors and extracellular matrix components.

Check Digit Verification of cas no

The CAS Registry Mumber 1239610-72-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,9,6,1 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1239610-72:
(9*1)+(8*2)+(7*3)+(6*9)+(5*6)+(4*1)+(3*0)+(2*7)+(1*2)=150
150 % 10 = 0
So 1239610-72-0 is a valid CAS Registry Number.

1239610-72-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (5E)-5-[[3-chloro-4-(2-cyclohexylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1239610-72-0 SDS

1239610-72-0Relevant academic research and scientific papers

NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF

-

Page/Page column 9, (2011/11/12)

The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and a pharmaceutical composition comprising the same. The novel thiazolidinedione derivatives of formula (I) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins as well as useful for the prevention of hair loss and the stimulation of hair growth, and osteogenic stimulation and wound healing.

Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors

Wu, Ying,Karna, Sandeep,Choi, Cheol Hee,Tong, Min,Tai, Hsin-Hsiung,Na, Dong Hee,Jang, Chul Ho,Cho, Hoon

, p. 5260 - 5264 (2011/10/09)

Novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors were synthesized. Compounds 2, 3, and 4 exhibited IC 50 of 25, 8, and 19 nM, respectively. They also significantly increased levels of PGE2 in A549 cells. To assess the influence of 15-PGDH inhibitor on cochlear blood flow (CBF), 2 was applied intravenously to guinea pigs. It increased their CBFs. Scratch wounds were also analyzed in confluent monolayers of HaCaT cells. Cells exposed to 4 showed significantly improved wound healing with respect to a control.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 1239610-72-0