123963-80-4

Basic information

• Product Name: tetrabutylammonium benzyl 2,2-dimethylmalonate
• CAS NO: 123963-80-4
• Molecular Weight: 463.701
• Mol File: 123963-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tetrabutylammonium benzyl 2,2-dimethylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: tetrabutylammonium benzyl 2,2-dimethylmalonate(123963-80-4)
• EPA Substance Registry System: tetrabutylammonium benzyl 2,2-dimethylmalonate(123963-80-4)

Safety Data

• Hazardous Substances Data: 123963-80-4(Hazardous Substances Data)

Upstream product

• 57772-82-4 dibenzyl dimethylmalonate 
• 86507-74-6 3-(benzyloxy)-2,2-dimethyl-3-oxopropanoic acid 
• 32503-27-8 tetra(n-butyl)ammonium hydrogensulfate 

Downstream Products

• 87343-27-9 <<3-(benzyloxy)-2,2-dimethylmalonyl>oxy>methyl penicillanate sulfone 

Relevant articles and documents

Orally effective acid prodrugs of the β-lactamase inhibitor sulbactam

Sulbactam (1) is a β-lactamase inhibitor with limited oral bioavailability. Lipophilic double-ester prodrug sulbactam pivoxil (2) significantly improves the oral absorption of sulbactam, as does the mutual prodrug double ester sultamicillin (3). We have found that double-ester prodrugs of sulbactam terminating in a carboxyl group (8) also were effective oral-delivery vehicles in rats. Carboxyl-terminated double esters have several potential advantages over their nonionizable lipophilic counterparts, including water solubility, crystallinity, choice of salts for dosage forms, and formation of innocuous byproducts on hydrolysis.