123975-54-2

Upstream product

• 60079-12-1 β-Methyl α-tert-butyl (2S)-N-(benzyloxycarbonyl)aspartate 
• 106-95-6 allyl bromide 
• 501-53-1 benzyl chloroformate 
• 3160-47-2 N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 

Downstream Products

• 177288-59-4 (2S,3S)-Pyrrolidine-1,2,3-tricarboxylic acid 1-benzyl ester 
• 177288-57-2 (2S,3R)-Pyrrolidine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester 
• 175225-10-2 (2S,3R)-2-Allyl-3-benzyloxycarbonylamino-succinic acid 
• 177288-58-3 (2S,3R)-Pyrrolidine-1,2,3-tricarboxylic acid 1-benzyl ester 3-methyl ester 
• 144787-23-5 2-((S)-1-(benzyloxycarbonylamino)-2-tert-butoxy-2-oxoethyl)pent-4-enoic acid 
• 177472-11-6 (2S,3R,5R)-5-Hydroxy-pyrrolidine-1,2,3-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 3-methyl ester 
• 177288-56-1 (2S,3R)-2-Benzyloxycarbonylamino-3-(2-oxo-ethyl)-succinic acid 1-tert-butyl ester 4-methyl ester 
• 177288-60-7 (2S,3R)-2-Allyl-3-benzyloxycarbonylamino-succinic acid 1-methyl ester 
• 127623-77-2 tert-butyl (S)-2-benzyloxycarbonylamino-6-hydroxyhex-5-enoate 

Relevant academic research and scientific papers

Asymmetric Synthesis of 3-Carboxyproline and Derivatives Suitable for Peptide Synthesis

An asymmetric synthesis of both diastereomers of 3-carboxyproline, as well as 5-substituted derivatives and partially protected derivatives suitable for peptide synthesis starting from aspartic acid is reported.

Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs

Novel inhibitors of asparagine synthetase, that will lower circulating levels of blood asparagine, have considerable potential in developing new protocols for the treatment of acute lymphoblastic leukemia. We now report the indirect characterization of th

Asymmetric Synthesis of (2S,3S)-3-Carboxy-Proline

An asymmetric synthesis of (2S,3S)-3-carboxy-proline starting from (S)-aspartic acid is reported.The methodology also allows the preparation of 5-substituted derivatives.

Non-Proteinogenic Amino Acid Synthesis. The β-Anion Derived from Aspartic Acid, and its Application to α-Amino Acid Synthesis.

Treatment of α-t-butyl β-methyl N-Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles.The application of this strategy for synthesis of optically active amino acids h

Asymmetric Amino Acid Synthesis: Preparation of the β Anion derived from Aspartic Acid

(S)-1-t-Butyl 4-methyl N-benzyloxycarbonylaspartate (5a), and (S)-1-t-butyl 4-allyl N-benzyloxycarbonylaspartate (5b) have been synthesized from (S)-aspartic acid (2), and can be readily alkylated and hydroxyalkylated at the β-carbon for asymmetric amino acid synthesis.