127623-77-2

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-[[(Benzyloxy)carbonyl]amino]-5-hexenoic Acid tert-Butyl Ester is used as a reactant for the preparation of collagen cross-links, pyridinoline and deoxypyridinoline, which are essential for maintaining the stability and integrity of collagen fibers in connective tissues. This makes it a valuable component in the development of treatments for various connective tissue disorders and degenerative diseases.
Used in Chemical Synthesis:
(2S)-2-[[(Benzyloxy)carbonyl]amino]-5-hexenoic Acid tert-Butyl Ester is used as a reactant in the synthesis of acyl derivatives of N-hydroxypyridine-2-thione. These derivatives have potential applications in various chemical processes and can be further modified to create new compounds with specific properties and functions.
Used in Research and Development:
(2S)-2-[[(Benzyloxy)carbonyl]amino]-5-hexenoic Acid tert-Butyl Ester is used as a research compound to study the properties and reactions of collagen cross-links and N-hydroxypyridine-2-thione derivatives. This helps scientists and researchers to better understand the mechanisms of these compounds and develop new strategies for their applications in various industries.

Upstream product

• 144787-23-5 2-((S)-1-(benzyloxycarbonylamino)-2-tert-butoxy-2-oxoethyl)pent-4-enoic acid 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 347888-69-1 (S)-2-Benzyloxycarbonylamino-5-oxo-pentanoic acid tert-butyl ester 
• 501-53-1 benzyl chloroformate 
• 606148-70-3 tert-butyl (2S)-2-aminohex-5-enoate 
• 6456-74-2 Glycine tert-butyl ester 
• 123975-54-2 t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-(2S)-hex-5-enoate 
• 60079-12-1 β-Methyl α-tert-butyl (2S)-N-(benzyloxycarbonyl)aspartate 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 
• 606148-69-0 (S)-2-[(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-hex-5-enoic acid tert-butyl ester 
• 136520-15-5 1,1-dimethylethyl N-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylidene]glycinate 
• 112157-39-8 Nα-(Benzyloxycarbonyl)-L-lysine tert-butyl ester 

Downstream Products

• 182422-50-0 (2S)-2-([(benzyloxy)carbonyl]amino)hex-5-enoic acid 
• 224629-58-7 (S)-2-benzyloxycarbonylamino-6-bromo-5-oxohexanoic acid tert-butyl ester 
• 309928-91-4 methyl (2S)-2-benzyloxycarbonylamino-6-bromo-5-oxohexanoate 
• 495401-22-4 (2S,5S)-2-benzyloxycarbonylamino-5-bromomethyl-δ-valerolactone 
• 495401-23-5 (2S,5R)-2-benzyloxycarbonylamino-5-bromomethyl-δ-valerolactone 
• 495401-24-6 methyl (2S,5S)-2-benzyloxycarbonylamino-6-bromo-5-hydroxyhexanoate 
• 441353-29-3 allyl (2S,5R)-2-benzyloxycarbonylamino-4-(2-oxiranyl)butanoate 
• 495401-21-3 tert-butyl (2S)-2-benzyloxycarbonylamino-6-bromo-5-hydroxyhexanoate 
• 495401-20-2 tert-butyl (S)-2-(((benzyloxy)carbonyl)amino)-6-hydroxyhexanoate 
• 63800-01-1 pyridinoline 
• 441353-32-8 allyl (2S,5S)-2-benzyloxycarbonylamino-5-hydroxy-6-iodohexanoate 
• 441353-36-2 allyl (2S)-2-benzyloxycarbonylamino-6-iodo-5-oxohexanoate 
• 441353-26-0 (2S,5R)-2-benzyloxycarbonylamino-5-iodomethyl-δ-valerolactone 
• 441353-27-1 (2S,5S)-2-benzyloxycarbonylamino-5-iodomethyl-δ-valerolactone 

Relevant academic research and scientific papers

INHIBITORS OF IAP

The invention provides novel compounds that are inhibitors of IAPs having the general formula: wherein X1, X2, X3, Y, A, R1, R2, R3, R4, R4', R5, R5'/

Inhibitors of IAP

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.

A simple modular synthesis of pyridinoline a collagen cross-link of biochemical interest

A simple convergent synthesis of the collagen cross-link pyridinoline starting from glycine is reported.

A simple and convenient transformation of L-lysine into pyridinoline and deoxypyridinoline, two collagen cross-links of biochemical interest

Starting from L-lysine as the only chiral building block, pyridinoline and deoxypyridinoline are efficiently synthesised, thus mimicking the postranscriptional formation of these collagen cross-links.

Stereoselective synthesis of allyl- and homoallylglycines

A new method for the synthesis of N-protected allyl- and homoallylglycines was developed from aspartic and glutamic acid derivatives. The carboxylic side-chains of aspartic and glutamic derivatives was first transformed into the Weinreb amide by coupling with N,O-dimethylhydroxylamine and then reduced into the corresponding aldehyde. The latter could react with methyl-triphenylphosphonium bromide to yield the title compounds with 50% total yield.

The invention of radical reactions. Part XXV. A convenient method for the synthesis of the acyl derivatives of N-hydroxypyridine-2-thione

Treatment of the readily available di-N-oxide - of 2-thiopyridine disulfide 6 with tributylphosphine in the presence of a carboxylic acid provides a convenient and high yielding synthesis of the acyl derivatives 2 of N-hydroxy-2-thio-pyridone. Application of this procedure to the acids 17 and 18 gave, after irradiation in the presence of t-butylthill, the desired decarboxylated derivatives in high (>90%) yield.

Non-Proteinogenic Amino Acid Synthesis. The β-Anion Derived from Aspartic Acid, and its Application to α-Amino Acid Synthesis.

Treatment of α-t-butyl β-methyl N-Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles.The application of this strategy for synthesis of optically active amino acids h