1239876-80-2

Upstream product

• 1623-92-3 4-phenoxyphenylsulfonyl chloride 
• 1239876-75-5 (S)-3-(4-phenoxybenzenesulfonamido)-2-(tritylamino)propanol 
• 1239876-78-8 (S)-2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propanol 
• 1239876-79-9 (R)-2-(benzyloxycarbonylamino)-3-(4-phenoxybenzenesulfonamido)propyl azide 
• 83877-27-4 diisopropyl 4-nitrophenoxycarbonylphosphonoformate 

Downstream Products

• 1239876-44-8 AV-70 

Relevant academic research and scientific papers

Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual-Action Anticancer MMP and Carbonic Anhydrase Inhibitors

Carbamoylphosphonates (CPOs) have recently been identified as extracellular in vivo active inhibitors of the cancer and metastasis-promoting extracellular enzymes, carbonic anhydrases (CAs) IX and XII, and matrix metalloproteinase-2 (MMP-2). This article

CARJBAMOYLPHOSPHONATES AS INHIBITORS AND USES THEREOF

The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP.