1239892-67-1Relevant academic research and scientific papers
A short enantioselective synthesis of ephedrine, amphetamine and their analogues via two stereocentered Co(III)-catalyzed hydrolytic kinetic resolution of racemic syn-benzyloxy epoxide
Lalwani, Komal G.,Sudalai, Arumugam
, p. 6488 - 6490 (2015)
An efficient route for the synthesis of 6 drugs belonging to phenethylamine and amphetamine classes in excellent overall yields and high optical purity has been described. The strategy involves introduction of stereogenic centers by means of two-stereocentered Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of racemic syn-benzyloxy epoxide followed by Pd-catalyzed regioselective cationic hydrogenation of amino alcohols as the key reactions.
PHENOLYTIC KINETIC RESOLUTION OF AZIDO AND ALKOXY EPOXIDES
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Page/Page column 17; 29, (2013/07/05)
Disclosed herein is a single step catalytic process for the production of enantiomerically pure ?-Aryloxy-?'-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (A). Formula A
Co(iii)(salen)-catalyzed HKR of two stereocentered alkoxy- and azido epoxides: A concise enantioselective synthesis of (S,S)-reboxetine and (+)-epi-cytoxazone
Reddy, R. Santhosh,Chouthaiwale, Pandurang V.,Suryavanshi, Gurunath,Chavan, Vilas B.,Sudalai, Arumugam
supporting information; experimental part, p. 5012 - 5014 (2010/08/07)
The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S,S)-reboxetine and (+)-epi-cytoxazone.
