1239902-39-6

Upstream product

• 335455-14-6 tert-butyl-(6-iodo-5-methyl-hex-5-enyloxy)-dimethyl-silane 
• 100-42-5 styrene 

Downstream Products

• 1194019-08-3 (E)-8-methyl-11-phenylundeca-1,2,8-trien-4-one 
• 1394313-84-8 (E)-7-methyl-1,1,10-triphenyldec-7-en-2-yn-1-ol 
• 1394313-85-9 (2E,7E)-7-methyl-1,1,10-triphenyldeca-2,7-dien-1-ol 

Relevant academic research and scientific papers

Enantioselective Polyene Cyclization Catalyzed by a Chiral Br?nsted Acid

The first enantioselective polyene cyclization initiated by a BINOL-derived chiral N-phosphoramide (NPA) catalyzed protonation of an imine is described. The ion-pair formed between the iminium ion and chiral counter anion of the NPA plays an important role for controlling the stereochemistry of the overall transformation. This strategy offers a highly efficient approach to fused tricyclic frameworks containing three contiguous stereocenters, which are widely found in natural products. In addition, the first catalytic asymmetric total synthesis of (?)-ferruginol was accomplished with an NPA catalyzed enantioselective polyene cyclization, as the key step for the construction of the tricyclic core, with excellent yield and enantioselectivity.