1239986-29-8

Basic information

• Product Name: 4-(3'-methylphenylamino)-2H-benzo[h]chromen-2-one
• CAS NO: 1239986-29-8
• Molecular Weight: 301.345
• Mol File: 1239986-29-8.mol

Chemical Properties

• CAS DataBase Reference: 4-(3'-methylphenylamino)-2H-benzo[h]chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3'-methylphenylamino)-2H-benzo[h]chromen-2-one(1239986-29-8)
• EPA Substance Registry System: 4-(3'-methylphenylamino)-2H-benzo[h]chromen-2-one(1239986-29-8)

Safety Data

• Hazardous Substances Data: 1239986-29-8(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 173210-20-3 4-Chloro-2H-naphtho<1,2-b>pyran-2-one 

Relevant articles and documents

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotoxic activity. Among all 4-substituted ABO analogs, cyclohexyl (12), N-methoxy-N-methylacetamide (14), and various aromatic derivatives (15-25 and 27) exhibited promising cell growth inhibitory activity with ED50 values of 0.01-5.8 μM against all tested tumor cell lines. The 4′-methoxyphenyl derivative (18) and 3′-methylphenyl derivative (24) showed the most potent antitumor activity against a broad range of cancer cell lines with ED50 values of 0.01-76 μM. Preliminary SAR results indicated that substitutions on nitrogen are critical to the antitumor potency.