1240040-97-4Relevant academic research and scientific papers
Synthesis of unsymmetrical ureas with coumarin and thiadiazole ring under microwave irradiation
Chai, Lan-Qin,Zhang, Hong-Song,Dong, Wen-Kui,Zhao, Yan-Ling
experimental part, p. 1332 - 1337 (2010/08/21)
A series of coumarin-3-yl substituted unsymmetrical ureas were synthesized by the reaction of 3-coumarin isocyanate, which was prepared from 3-coumarinyl azide by Curtius rearrangement, with various aromatic amines, 2-amino-5-phenyl-1,3,4-thiadiazole, and 2-amino-5-aryloxymethylene-1,3,4- thiadiazoles under microwave irradiation. Compared to conventional methods, this synthesis has the advantages of mild reaction conditions, easy handling, and high yields. The products have been characterized by analytical and spectral (IR and 1H NMR) data. Copyright Taylor & Francis Group, LLC.
