364360-13-4

Basic information

• Product Name: 1,3,4-Thiadiazol-2-aMine, 5-[(4-Methoxyphenoxy)Methyl]-
• Synonyms: 1,3,4-Thiadiazol-2-aMine, 5-[(4-Methoxyphenoxy)Methyl]-;2-Amino-5-(4-methoxyphenoxy)methyl-1,3,4-thiadiazole;2-Amino-5-(4-methoxyphenoxymethylene)-1,3,4-thiadiazole
• CAS NO: 364360-13-4
• Molecular Formula: C₁₀H₁₁N₃O₂S
• Molecular Weight: 237.27824
• Mol File: 364360-13-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130-133℃ (ethanol )
• Boiling Point: 449.4±51.0 °C(Predicted)
• Appearance: /
• Density: 1.345±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.91±0.10(Predicted)
• CAS DataBase Reference: 1,3,4-Thiadiazol-2-aMine, 5-[(4-Methoxyphenoxy)Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Thiadiazol-2-aMine, 5-[(4-Methoxyphenoxy)Methyl]-(364360-13-4)
• EPA Substance Registry System: 1,3,4-Thiadiazol-2-aMine, 5-[(4-Methoxyphenoxy)Methyl]-(364360-13-4)

Safety Data

• Hazardous Substances Data: 364360-13-4(Hazardous Substances Data)

Usage

General Description

1,3,4-Thiadiazol-2-amine, 5-[(4-methoxyphenoxy)methyl]- is an organic compound that belongs to the thiadiazole family. It is synthesized by substituting the amine group of 1,3,4-thiadiazol-2-amine with a 5-[(4-methoxyphenoxy)methyl] group. This chemical has potential uses in pharmaceuticals and agrochemicals due to its structural features, which make it suitable for various biological activities. Its aromatic and heterocyclic nature makes it a versatile compound for the development of new drugs and chemical formulations for crop protection. Further research and study are required to explore its full potential and applications in various industries.

InChI:InChI=1S/C10H11N3O2S/c1-14-7-2-4-8(5-3-7)15-6-9-12-13-10(11)16-9/h2-5H,6H2,1H3,(H2,11,13)

Upstream product

• 1200-06-2 4-methoxyphenyl acetate 
• 79-19-6 thiosemicarbazide 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 150-76-5 4-methoxy-phenol 
• 21953-91-3 (4-methoxyphenoxy)acetic acid hydrazide 
• 18598-23-7 ethyl (4-methoxyphenoxy)acetate 
• 928710-47-8 2-({[4-(methyloxy)phenyl]oxy}acetyl)hydrazinecarbothioamide 

Downstream Products

• 1263183-56-7 7-methyl-2-(4-methoxy)-phenoxymethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 1357853-49-6 C₂₃H₂₄N₄O₃S 
• 876886-39-4 C₁₁H₁₀N₄O₂S 
• 1374985-02-0 C₁₀H₉ClN₂O₂S 
• 1227624-45-4 C₁₁H₁₁N₃O₃S 
• 1240040-97-4 C₂₀H₁₆N₄O₅S 
• 453557-59-0 2-(5-(2-nitrophenyl)-2-furoylamido)-5-(4-methoxyphenyloxymethyl)-1,3,4-thiadiazole 

Relevant articles and documents

Preparation of 2-amino-5-alkyl -1, 3, 4-thiadiazole

The invention discloses a method for preparing 2-amino-5-alkyl-1,3,4-thiadiazole. The method comprises the following steps of adding A mol of thiosemicarbazide, B mol of carboxylic acid, C mol of phosphorus oxychloride and D mol of silica gel in a dry reaction container, grinding at a room temperature until the raw materials are completely reacted, and standing to obtain a crude product, wherein A: B: C = 1: (1 to 1.2): (1 to 1.2), and A: D = 1: (5 to 10); then adding alkaline solution in the crude product until the pH value of the obtained mixed solution is 8-8.2, then carrying out suction filtration on the mixed solution, dissolving the filter cake by a solvent and then further carrying out suction filtration, removing silica gel, then carrying out reduced pressure concentration on the finally-obtained filtrate, and removing the solvent to obtain 2-amino-5-alkyl-1,3,4-thiadiazole. The method disclosed by the invention is a solid-phase reaction, silica gel is used as a carrier, the operation process is simple, the reaction time is short, the reaction conditions are moderate, the equipment requirements are low, and the yield of the target product is up to more than 91%.

Synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with potential bioactivity in PEG-400

An environmental benign procedure for synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles has been developed by reaction of 2-amino-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with formic acid in PEG-400. The key advantages of this protocol are

Solvent-free synthesis of 2-amino-5-aryloxymenthyl-1,3,4-thiadiazoles and their coumarin or benzofuran bis-heterocyclic derivatives

2-amino-5-aryloxymethyl-1,3,4-thiadiazoles were synthesized rapidly by a microwave-accelerated solvent-free procedure in high yield via the condensation of thiosemicarbazide with aryloxyacetic acids using poly(ethylene glycol)-supported dichlorophosphate