124010-40-8Relevant academic research and scientific papers
Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives
Serra, Silvia,Delogu, Giovanna,Casu, Laura,Vazquez-Rodriguez, Saleta,Santana, Lourdes,Uriarte, Eugenio,Chicca, Andrea,Gertsch, Juerg
, p. 5791 - 5794,4 (2020/07/31)
Coumarins are a large family of natural and synthetic compounds exerting different pharmacological effects, including cytotoxic, anti-inflammatory or antimicrobial. In the present communication we report the synthesis of a series of 12 diversely substituted 4-oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their anti-proliferative effects on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoma cells (Neuro2a). The most potent bioactive molecule was the 4-hydroxy-5,7- dimethoxycoumarin (compound 1) which showed similar potency (IC50 0.2-2 μM) in all cancer cell lines tested. This non-natural product reveals a simple bioactive scaffold which may be exploited in further studies.
Application of Aryllead(IV) Derivatives to the Preparation of 3-Aryl-4-hydroxy-1-benzopyran-2-ones
Barton, Derek H. R.,Donnelly, Dervilla M. X.,Finet, Jean-Pierre,Guiry, Patrick J.
, p. 1365 - 1376 (2007/10/02)
Aryllead triacetates are chemoselective and regioselective reagents for the preparation of 3-aryl-4-hydroxy-1-benzopyran-2-ones in good to excellent yields by C-3 arylation of the preformed 4-hydroxy-1-benzopyran-2-one ring.This approach was applied to th
A FACILE SYNTHESIS OF 3-ARYL-4-HYDROXYCOUMARINS
Barton, Derek H.R.,Donelly, Dervilla M.X.,Finet, Jean-Pierre,Guiry, Patrick J.
, p. 1539 - 1542 (2007/10/02)
A range of 3-aryl-4-hydroxycoumarins have been prepared by direct arylation of 4-hydroxycoumarin derivatives by variously substituted aryllead triacetates.Yields were temperature and substituent dependent.
