1240307-96-3Relevant academic research and scientific papers
Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines
Genoni, Andrea,Benaglia, Maurizio,Massolo, Elisabetta,Rossi, Sergio
supporting information, p. 8365 - 8367 (2013/09/23)
The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.
Synthesis of N-aryl trifluoromethylarylketoimines by palladium-catalyzed Suzuki coupling reaction of N-aryltrifluoroacetimidoyl chlorides with aryl boronic acids
Li, Chun-Lin,Chen, Mu-Wang,Zhang, Xing-Guo
experimental part, p. 856 - 860 (2010/09/05)
A highly efficient Suzuki reaction between N-aryltrifluoroacetimidoyl chlorides and aryl boronic acids using Pd(PPh3)4 as a catalyst has been developed. This route allows for selective synthesis of N-aryl trifluoromethylarylketoimines in high yields under mild reaction conditions.
