1240324-91-7Relevant academic research and scientific papers
Isoprene as lithiation mediator: Synthesis of 2-substituted 1-alkylimidazole derivatives
Martinez, Regina,Torregrosa, Rosario,Pastor, Isidro M.,Yus, Miguel
experimental part, p. 2630 - 2638 (2012/09/07)
The lithiation of different imidazoles bearing a primary (i.e., butyl, pentyl, dodecyl) or secondary (i.e., cyclohexyl, 1-methylheptyl) alkyl substituent on the nitrogen has been successfully achieved by means of an isoprene-mediated protocol. The subsequent reaction of the 2-lithioimidazole intermediates with different electrophiles leads to the formation of interesting 1,2-disubstituted imidazoles. Georg Thieme Verlag Stuttgart · New York.
Isoprene-mediated lithiation of 1-alkylimidazoles: Chiral induction of the alkyl substituent
Pastor, Isidro M.,Torregrosa, Rosario,Yus, Miguel
experimental part, p. 373 - 376 (2011/04/12)
The isoprene-mediated lithiation of imidazoles bearing a secondary alkyl substituent at the nitrogen (7, 8 and 13) and the subsequent nucleophilic addition to different electrophiles allows the preparation of the corresponding 2-functionalized imidazoles
