1240361-07-2

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 119072-55-8 tert-butylisonitrile 
• 1240361-06-1 2-tert-butoxycarbonylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 
• 100-46-9 benzylamine 
• 1313712-54-7 C₁₅H₂₁NO₄S 
• 108354-78-5 methyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 108-94-1 cyclohexanone 

Downstream Products

• 1240361-08-3 C₂₃H₂₇N₃O₃S 

Relevant academic research and scientific papers

1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity

1,4-Thienodiazepine-2,5-diones have been synthesized via the Ugi-Deprotection-Cyclization (UDC) approach starting from Gewald 2-aminothiophenes in a convergent and versatile manner. The resulting scaffold is unprecedented, cyclic, and peptidomimetic with four points of diversity introduced from readily available starting materials. In addition to eighteen synthesized and characterized compounds, a virtual compound library was generated and evaluated for chemical space distribution and drug-like properties. A small focused compound library of 1,4-thienodiazepine-2,5-diones has been screened for the activity against p53-Mdm2 interaction. Biological evaluations demonstrated that some compounds exhibited promising antagonistic activity.