1240483-66-2

Basic information

• Product Name: 3,4-dihydro-7-methoxy-4-(3,4,5-trimethoxyphenyl)-2H-naphtho[2,3-b]pyran-2-one
• CAS NO: 1240483-66-2
• Molecular Weight: 394.424
• Mol File: 1240483-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dihydro-7-methoxy-4-(3,4,5-trimethoxyphenyl)-2H-naphtho[2,3-b]pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-7-methoxy-4-(3,4,5-trimethoxyphenyl)-2H-naphtho[2,3-b]pyran-2-one(1240483-66-2)
• EPA Substance Registry System: 3,4-dihydro-7-methoxy-4-(3,4,5-trimethoxyphenyl)-2H-naphtho[2,3-b]pyran-2-one(1240483-66-2)

Safety Data

• Hazardous Substances Data: 1240483-66-2(Hazardous Substances Data)

Upstream product

• 5111-66-0 6-Methoxy-2-naphthol 
• 7560-49-8 3,4,5-trimethoxycinnamic acid methyl ester 

Relevant articles and documents

Design and synthesis of C-ring lactone- and lactam-based podophyllotoxin analogues as anticancer agents

A series of novel podophyllotoxin (PDT) analogues was synthesized in which the lactone moiety was shifted to C ring. Some of the derivatives were also synthesized with modified A ring. Analogues 23 and 25 exhibited potent in vitro cytotoxicity against colon cancer (CaCO2) cell line. p-Demethylated E-ring analogues exhibited better potency than the corresponding methylated analogues. These analogues showed toxicity comparable to PDT against human erythrocytes albeit at much higher concentrations (100 μg/ml) than their cytotoxicity values.