5111-66-0

Basic information

• Product Name: 6-Methoxy-2-naphthol
• Synonyms: 6-METHOXY-2-NAPHTHOL;6-METHOXY-NAPHTHALEN-2-OL;2-HYDROXY-6-METHOXYNAPHTHALENE;Naproxen EP IMpurity H;6-Methoxy-2-naphthol >=97.0% (HPLC)
• CAS NO: 5111-66-0
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.2
• EINECS: 1533716-785-6
• Product Categories: Aromatic Phenols;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 5111-66-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 148-152 °C
• Boiling Point: 336.7 °C at 760 mmHg
• Flash Point: 211.8 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 5.65E-05mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.76±0.40(Predicted)
• Stability: Light Sensitive
• BRN: 2043873
• CAS DataBase Reference: 6-Methoxy-2-naphthol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-2-naphthol(5111-66-0)
• EPA Substance Registry System: 6-Methoxy-2-naphthol(5111-66-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 8-9-23
• Hazardous Substances Data: 5111-66-0(Hazardous Substances Data)

Usage

Uses

6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.

InChI:InChI=1/C11H10O2/c1-13-11-5-3-8-6-10(12)4-2-9(8)7-11/h2-7,12H,1H3

Upstream product

• 5408-86-6 2,3-dibromobutane 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 581-43-1 2.6-dihydroxynaphthalene 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 13101-88-7 6-methoxy-2-naphthylamine 
• 170889-47-1 diphenyl 2,2'-dihydroxy-[1,1'-binaphthalene]-3,3'-dicarboxylate 
• 5486-55-5 2,6-dimethoxylnaphthalene 
• 1240483-66-2 3,4-dihydro-7-methoxy-4-(3,4,5-trimethoxyphenyl)-2H-naphtho[2,3-b]pyran-2-one 
• 1402577-15-4 (6-methoxynaphthalen-2-yl)diphenylphosphine oxide 
• 1619263-45-4 C₂₄H₁₉ClN₂O₆S 
• 86539-78-8 acetyl-1 methoxy-6 naphtol-2 
• 1597709-86-8 4-[(2-hydroxy-6-methoxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-2,3-dihydro-1H-pyrazol-3-one 

Relevant articles and documents

NAPHTHALENE-CONTAINING POLYMERS AND METHODS OF MAKING THE SAME

The present disclosure relates to a dimer that includes a first hydroxyl-functionalized naphthalene group and a second hydroxyl-functionalized naphthalene group, where the first hydroxyl-functionalized naphthalene group and the second hydroxyl-functionalized naphthalene group are connected by a bridging group. The present disclosure also relates to a polymer synthesized using the dimer, as well as methods for synthesizing both the dimer and the polymer.

HALOGENATION REGIOSELECTIVE EN SERIE AROMATIQUE-II CHLORATION DES NAPHTOLS ET LEURS ETHERS A L'AIDE DE REACTIFS METTANT EN JEU DES INTERACTIONS DU TYPE DONNEUR-ACCEPTEUR

The regispecific chlorination of naphtols by hexachlorocyclohexadienones as selective chlorinating reagents is described.The selectivity attained is better than that which we have obtained with phenol derivatives and confirms the importance of the donor-acceptor interaction between the reagent and the naphthol during the chlorination.