1240490-37-2Relevant academic research and scientific papers
Synthesis of the azetidinyl-thiazoline fragment of vioprolides A and C
Chopin, Nathalie,Couty, Francois,Evano, Gwilherm
, p. 353 - 359 (2011/04/12)
An efficient synthesis of the azetidinyl-thiazoline fragment of the antifungal and cytotoxic macrolides vioprolides A and C is reported. Key steps of the synthesis include formation of the thiazoline by condensation of NAlloc-trans (2S,4R)-4-methylazetidine-2-carbonitrile with L-cysteine and formation of the four-membered ring by intramolecular alkylation of a suitably protected N-Alloc derivative prepared from (R)-alaninol.
