124050-14-2

Basic information

• Product Name: Benzothiazole, 2-(chloromethyl)-6-fluoro- (9CI)
• Synonyms: Benzothiazole, 2-(chloromethyl)-6-fluoro- (9CI);2-Chloromethyl-6-fluorobenzothiazole;2-Chloromethyl-6-fluorobenzo[d]thiazole, 97%
• CAS NO: 124050-14-2
• Molecular Formula: C₈H₅ClFNS
• Molecular Weight: 201.6484032
• Product Categories: BENZOTHIAZOLE
• Mol File: 124050-14-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzothiazole, 2-(chloromethyl)-6-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-(chloromethyl)-6-fluoro- (9CI)(124050-14-2)
• EPA Substance Registry System: Benzothiazole, 2-(chloromethyl)-6-fluoro- (9CI)(124050-14-2)

Safety Data

• Hazardous Substances Data: 124050-14-2(Hazardous Substances Data)

Upstream product

• 348-40-3 2-amino-6-fluoro-1,3-benzothiazole 
• 51076-95-0 2-chloro-1,1,1-triethoxyethane 
• 33264-82-3 5-fluoro-2-aminobenzenethiol 

Downstream Products

• 139425-06-2 3-(6-fluorobenzothiazol-2-ylmethoxy)benzyl alcohol 

Relevant articles and documents

Highly selective aldose reductase inhibitors. II. Optimization of the aryl part of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids

Accumulation of intracellular sorbitol, the product of glucose reduction catalyzed by aldose reductase (AR) [EC 1.1.1.21], is thought to be the main culprit in the development of diabetic complications. A series of 3- arylalkyl-2,4,5-trioxoimidazolidine-1-acetic acids was prepared and tested for inhibitory activities towards AR and aldehyde reductase (ALR) [EC 1.1.1.2]. These derivatives showed strong inhibitory activity against AR without markedly inhibiting ALR. In particular, the compounds with 3- nitrophenyl, 4-chloro-3-nitrophenyl, and chloro-substituted benzothiazolyl groups as the aryl part showed powerful AR-inhibitory activity. The chloro- substituted benzothiazolyl compound showed an AR selectivity of more than 5000 fold.