1240503-91-6Relevant academic research and scientific papers
Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids
Feng, Li-Chun,Sun, Ya-Wei,Tang, Wei-Jun,Xu, Li-Jin,Lam, Kim-Lung,Zhou, Zhongyuan,Chan, Albert S. C.
, p. 949 - 952 (2010)
The room temperature ionic liquid [bmim][PF6] has been demonstrated to be an efficient and recyclable medium for highly chemoselective synthesis of 2,2-dimethyl-6-substituted 4-piperidones via a l-proline catalyzed tandem Mannich reaction of ammonia, aldehydes and acetone, and good yields were achieved for aryl and alkyl aldehydes.
