1240642-74-3Relevant academic research and scientific papers
FLUORESCENT NITRIC OXIDE PROBES AND ASSOCIATED METHODS
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Paragraph 0056; 0058, (2013/11/19)
Nitric oxide probes comprising a compound represented by Formula, I, II, III, IV, V, VI or a combination thereof are provided. Methods of using these nitric oxide probes to detect nitric oxide are also provided.
A highly selective low-background fluorescent imaging agent for nitric oxide
Yang, Youjun,Seidlits, Stephanie K.,Adams, Michelle M.,Lynch, Vincent M.,Schmidt, Christine E.,Anslyn, Eric V.,Shear, Jason B.
supporting information; experimental part, p. 13114 - 13116 (2010/12/18)
We introduce a novel sensing mechanism for nitric oxide (NO) detection with a particular easily synthesized embodiment (NO550), which displays a rapid and linear response to NO with a red-shifted 1500-fold turn-on signal from a dark background. Excellent selectivity was observed against other reactive oxygen/nitrogen species, pH, and various substances that interfere with existing probes. NO550 crosses cell membranes but not nuclear membranes and is suitable for both intra-and extracellular NO quantifications. Good cytocompatibility was found during in vitro studies with two different cell lines. The high specificity, dark background, facile synthesis, and low pH dependence make NO550 a superior probe for NO detection when used as an imaging agent.
