124068-98-0

Basic information

• Product Name: 4-chlorophenyl benzylcarbamate
• CAS NO: 124068-98-0
• Molecular Formula: C₁₄H₁₂ClNO₂
• Molecular Weight: 261.7036
• Mol File: 124068-98-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 383.8°C at 760 mmHg
• Flash Point: 185.9°C
• Density: 1.254g/cm³
• Vapor Pressure: 4.29E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 4-chlorophenyl benzylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorophenyl benzylcarbamate(124068-98-0)
• EPA Substance Registry System: 4-chlorophenyl benzylcarbamate(124068-98-0)

Safety Data

• Hazardous Substances Data: 124068-98-0(Hazardous Substances Data)

Upstream product

• 106-48-9 4-chloro-phenol 
• 3173-56-6 benzyl isothiocyanate 
• 90609-83-9 S-Methyl N-benzyl(thiocarbamate) 
• 65263-72-1 N-benzyl O-methyl thiocarbamate 
• 132905-83-0 Carbonic acid chloromethyl ester 4-chloro-phenyl ester 
• 100-46-9 benzylamine 

Relevant articles and documents

Investigation of salicylanilide and 4-chlorophenol-based N-monosubstituted carbamates as potential inhibitors of acetyl- and butyrylcholinesterase

Based on the presence of carbamate moiety, twenty salicylanilide N-monosubstituted carbamates concomitantly with their parent salicylanilides and five newly prepared 4-chlorophenyl carbamates obtained from isocyanates were investigated using Ellman's method for their in vitro inhibitory activity against acetylcholinesterase (AChE) from electric eel and butyrylcholinesterase (BChE) from equine serum. The carbamates and salicylanilides exhibited mostly a moderate inhibition of both cholinesterase enzymes with IC50 values ranging from 5 to 235 μM. IC50 values for AChE were in a narrower concentration range when compared to BChE, but many of the compounds produced a balanced inhibition of both cholinesterases. The derivatives were comparable or superior to rivastigmine for AChE inhibition, but only a few of carbamates also for BChE. Several structure-activity relationships were identified, e.g., N-phenethylcarbamates produce clearly favourable BChE inhibition. The compounds also share convenient physicochemical properties for CNS penetration.

An easy and efficient one-step procedure for the preparation of alkyl and aryl alkylcarbamates from S-methyl N-alkylthiocarbamates

A general, one-step procedure for the synthesis of alkyl and aryl alkylcarbamates, by the direct reaction of S-methyl N-alkylthiocarbamates with alcohols or phenols in toluene at reflux in the presence of triethylamine, is reported. All the target products were obtained in high yield (15 examples, average yield 94%) and very high purity (>99.2%). The recovery of a co-product of industrial interest, methanethiol, in an amount of one mole for each mole of thiocarbamate, with complete exploitation of the reagent, should also be noted. Georg Thieme Verlag Stuttgart.

α-Haloalkyl Haloformates and Related Compounds 1. A Convenient Synthesis of Carbamates via Chloromethyl Carbamates

The preparation of carbamates under mild conditions utilizing a new class of activated carbonates (containing chloromethyl function) is described.