124072-89-5

Basic information

• Product Name: HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE
• Synonyms: Tetrahydropyridazine dihydrochloride;1,2‐diazinane dihydrochloride;HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE;Pyridazine,hexahydro-,hydrochloride(1:2)
• CAS NO: 124072-89-5
• Molecular Formula: C₄H₁₀N₂*2ClH
• Molecular Weight: 159.05748
• Mol File: 124072-89-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 135-137℃
• Boiling Point: 202.7 °C at 760 mmHg
• Flash Point: 76.4 °C
• Appearance: /
• Vapor Pressure: 0.242mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE(124072-89-5)
• EPA Substance Registry System: HEXAHYDROPYRIDAZINE DIHYDROCHLORIDE(124072-89-5)

Safety Data

• Hazardous Substances Data: 124072-89-5(Hazardous Substances Data)

Usage

Uses

Hexahydropyridazine Dihydrochloride is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the synthesis of completely hydrogenated dipiperidazino tetrazine, tetrazepine and tetrazone derivatives.

InChI:InChI=1/C4H10N2.2ClH/c1-2-4-6-5-3-1;;/h5-6H,1-4H2;2*1H

Upstream product

• 340256-13-5 tert-butyl 2-[(tert-butyl)oxycarbonyl]perhydropyridazine-1-carboxylate 
• 189807-28-1 tetrahydropyridazine-1,2-dicarbaldehyde 
• 110-52-1 1,4-dibromo-butane 

Downstream Products

• 939964-17-7 (R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 69386-74-9 3-amino-5,6,7,8-tetrahydro-1H-pyrazolo[1,2-a]pyridazin-1-one 

Relevant articles and documents

Preparation method of hexahydropyridazine dihydrochloride

The invention relates to a preparation method of hexahydropyridazine dihydrochloride, which comprises the following steps: reacting formic acid with hydrazine hydrate to generate N,N'-diformylhydrazine; then reacting the N,N'-diformylhydrazine with 1,4-dibromobutane under the alkaline condition to generate tetrahydropyridazine-1,2-diformaldehyde; and finally reacting the tetrahydropyridazine-1,2-diformaldehyde with hydrochloric acid to generate the hexahydropyridazine dihydrochloride. Compared with the prior art, the method provided by the invention has the advantages of easily available and cheap raw materials, mild reaction, simple operation, low requirements on reaction equipment, and easy industrialization.

Substituted Pyrazalones

The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such a

Biginelli reactions catalyzed by hydrazine type organocatalyst

Pyrazolidine dihydrochloride can be used in the acceleration of Biginelli reactions between urea, ethyl acetoacetate and various aldehydes to provide DHPMs in good to excellent yields.