124072-89-5

Usage

Uses

Used in Pharmaceutical Industry:
Hexahydropyridazine Dihydrochloride is used as a reagent for the synthesis of completely hydrogenated dipiperidazino tetrazine, tetrazepine, and tetrazone derivatives. These synthesized compounds have potential applications in the development of new drugs and therapeutic agents, contributing to advancements in medicine and healthcare.
Used in Chemical Research:
In the field of chemical research, Hexahydropyridazine Dihydrochloride is employed as a reagent to explore new chemical reactions and pathways. Its use in the synthesis of complex organic molecules aids researchers in understanding the underlying mechanisms and properties of these compounds, furthering scientific knowledge and innovation.

InChI:InChI=1/C4H10N2.2ClH/c1-2-4-6-5-3-1;;/h5-6H,1-4H2;2*1H

Upstream product

• 340256-13-5 tert-butyl 2-[(tert-butyl)oxycarbonyl]perhydropyridazine-1-carboxylate 
• 110-52-1 1,4-dibromo-butane 
• 189807-28-1 tetrahydropyridazine-1,2-dicarbaldehyde 

Downstream Products

• 939964-17-7 (R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 69386-74-9 3-amino-5,6,7,8-tetrahydro-1H-pyrazolo[1,2-a]pyridazin-1-one 

Relevant academic research and scientific papers

Preparation method of hexahydropyridazine dihydrochloride

The invention relates to a preparation method of hexahydropyridazine dihydrochloride, which comprises the following steps: reacting formic acid with hydrazine hydrate to generate N,N'-diformylhydrazine; then reacting the N,N'-diformylhydrazine with 1,4-dibromobutane under the alkaline condition to generate tetrahydropyridazine-1,2-diformaldehyde; and finally reacting the tetrahydropyridazine-1,2-diformaldehyde with hydrochloric acid to generate the hexahydropyridazine dihydrochloride. Compared with the prior art, the method provided by the invention has the advantages of easily available and cheap raw materials, mild reaction, simple operation, low requirements on reaction equipment, and easy industrialization.

HERBICIDAL BENZOXAZINONES

The present invention provides benzoxazinones of formula I wherein R1 is hydrogen or halogen; R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3/

Substituted Pyrazalones

The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such a

Development of cyclic hydrazine and hydrazide type organocatalyst-mechanistic aspects of cyclic hydrazine/hydrazide-catalyzed diels-alder reactions

Some hydrazines and hydrazides were prepared and screened for their catalytic efficiencies in Diels-Alder reactions. 1H-NMR studies and ab initio calculations revealed that catalytic efficiencies of these catalysts are greatly dependent on the release of the catalysts from the Diels-Alder adducts.

Biginelli reactions catalyzed by hydrazine type organocatalyst

Pyrazolidine dihydrochloride can be used in the acceleration of Biginelli reactions between urea, ethyl acetoacetate and various aldehydes to provide DHPMs in good to excellent yields.

Synthesis, biological evaluation and structural determination of β-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors

Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of β-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)but an-1-one (10f), showed potent in vitro activity, good selectivity and in vivo efficacy in mouse models. Also, the binding mode of compound 10f was determined by X-ray crystallography.

Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye

Disclose herein is a composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolones and addition salts thereof, at least one coupler, and at least one heterocyclic direct dye. Also disclosed herein is a method for dyeing keratin fibers comprising applying a composition of the present disclosure to the keratin fibers. The compositions and methods of the present disclosure may make it possible to obtain fast coloration of keratin fibers that is resistant to light and/or to washing.

NAPHTHALENE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR

The present invention relates to naphthalene derivatives of formula (I) that are modulators of the glucocorticoid receptor, and to processes for the preparation and use of the same.

NOVEL CATHEPSIN C INHIBITORS AND THEIR USE

The invention is directed to novel cathepsin C inhibitors and their use in the treatment of diseases mediated by the cathepsin C enzyme. Specifically, the invention is directed to compounds according to Formula (I): wherein X and n are defined below, and

Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer

The present disclosure relates to a composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolone compounds and addition salts thereof, at least one coupler and at least one associative polyurethane polymer, and also to a dyeing process and kit using such a composition. The present disclosure makes it possible, for instance, to obtain fast coloration of keratin fibers that is resistant to light and to washing.