1240790-62-8Relevant articles and documents
Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives
Yang, Ya Jun,Yang, Ya Nan,Jiang, Jian Shuang,Feng, Zi Ming,Liu, Hong Yan,Pan, Xian Dao,Zhang, Pei Cheng
, p. 902 - 904 (2011/11/30)
A series of heterocycle-substituted phthalimide derivatives were synthesized. Structurally diverse derivatives with heterocyclic rings, including furan, imidazo[1,2-a]pyridine, 1,3,4-thiadiazine, imidazo[2,1-b][1,3,4] thiadiazine, pyrazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine, thiazole and thiazoline, were obtained by the reactions of α-bromoketone intermediate with various nucleophiles containing oxygen, nitrogen and sulfur atom. Their cytotoxic activity was also evaluated against five human cancer cell lines in vitro.
