70386-38-8

Basic information

• Product Name: 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE
• Synonyms: 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE;2-(3-Bromo-1-methyl-2-oxopropyl)-1H-isoindole-1,3-(2H)-dione;N-(3-Bromo-1-methyl-2-oxopropyl)phthalimide;2-(4-bromo-3-oxobutan-2-yl)-2,3-dihydro-1H-isoindole-1,3-dione
• CAS NO: 70386-38-8
• Molecular Formula: C₁₂H₁₀BrNO₃
• Molecular Weight: 296.12
• Mol File: 70386-38-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE(70386-38-8)
• EPA Substance Registry System: 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE(70386-38-8)

Safety Data

• Hazardous Substances Data: 70386-38-8(Hazardous Substances Data)

Usage

Molecular structure

2-(3-Bromo-1-methyl-2-oxopropyl)-LH-isindole-1,3-(2H)-dione is a derivative of isatin, with a 2-oxopropyl group, a bromine atom, and a methyl group attached to the isindole ring structure.

Type of compound

It is an organic compound.

Potential applications

The molecule has potential applications in medicinal chemistry and drug development.

Structural features

The compound's structural features, including the bromine atom and the 2-oxopropyl and methyl groups, contribute to its potential biological activities.

Specific properties and uses

These can vary depending on the specific applications and research interests of the individuals or organizations working with the compound.

Upstream product

• 186581-53-3 diazomethane 
• 53701-47-6 2-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 
• 77202-58-5 1-diazo-3-phthalimido-2-butanone 
• 21860-84-4 2-phthalimidopropionic acid 
• 4192-28-3 N-phthalyl-L-alanine 
• 85-44-9 phthalic anhydride 
• 4306-25-6 L-2-methyl-2-(phthalimido)acetyl chlorid 
• 2028-33-3 2-(1-methyl-2-oxo-propyl)-isoindole-1,3-dione 

Downstream Products

• 1298016-93-9 C₁₉H₁₅ClN₄O₂S 
• 1298016-94-0 C₂₀H₁₈N₄O₂S 
• 1298017-06-7 C₂₀H₁₇ClN₄O₂S 
• 1298017-05-6 C₁₉H₁₅FN₄O₂S 
• 1298017-17-0 C₂₆H₂₀N₄O₃S 
• 1298017-16-9 C₂₁H₁₈N₄O₃S 
• 1240790-62-8 C₂₁H₁₆N₄O₂S 
• 1298017-04-5 C₂₀H₁₈N₄O₂S 
• 1298016-91-7 C₁₉H₁₆N₄O₂S 
• 1298016-95-1 C₁₉H₂₂N₄O₂S 
• 1298017-02-3 C₂₀H₁₈N₄O₃S 
• 1298016-92-8 C₁₉H₁₅FN₄O₂S 
• 1298016-99-5 C₁₉H₁₅N₅O₄S 
• 1341189-36-3 C₁₉H₁₈N₄O₂S 

Relevant articles and documents

Synthesis and antiviral activity of novel 1,3,4-thiadiazine derivatives

A series of novel 1,3,4-thiadiazine derivatives were synthesized via chemical optimization on phthiobuzone. Their anti-herpes simplex virus (HSV) activities in vitro were also tested. Several compounds exhibited more highly potent anti-HSV activity and much higher selectivity index (SI) values than those of phthiobuzone. The most potent anti-HSV compound was 4f, which showed marked inhibition against HSV-1 (IC50=77.04μg/ml) and HSV-2 (IC50=30.00μg/ml). Meanwhile it had low cytotoxicity (CC 50=1000.00μg/ml), resulting in high (SIHSV-1= 12.98, SIHSV-2=33.33, respectively). Furthermore, a computational study for prediction of absorption, distribution, metabolism, excretion (ADME) properties of compound 4f was performed by determination of topological polar surface area, absorption and Lipinski parameters.

Synthesis and antiviral activity of phthiobuzone analogues

A series of phthiobuzone analogs, prepared from potassium phthalimide or phthalandione, have been evaluated for their antiviral activities. Among the candidates, compounds 5j and 5k, which contain the substituted 4-halogenated phenyl ring at N-4′,4″ position, show more potent antiviral activity than phthiobuzone against herpes simplex virus 1 (IC50=8.56 and 2.85 μ/ml, respectively) and herpes simplex virus 2 (IC50=1.75 and 4.11μg/ ml, respectively). Compounds 9c and 9d with a propylene linker between the phthalimide and bisthiosemicarbazone moieties display similar antiviral potency against herpes simplex virus 1 (IC50=2.85 and 4.11 μg/ml, respectively).

SULFUR YLIDES. 3. SYNTHESIS OF KETO-GROUP STABILIZED AMINO-CONTAINING SULFUR YLIDES FROM AMINO ACIDS

An effective path of synthesis was developed of new synthetic intermediates, the optically active, keto-group stabilized amino-substituted sulfur ylides.