1240792-17-9

Upstream product

• 107301-61-1 N-benzyl-4-amino-1-butyne 
• 100-46-9 benzylamine 

Downstream Products

• 1240791-75-6 N-benzyl-1-methyl-2,5-dioxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide 
• 1240791-71-2 N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide 
• 1240791-76-7 N,1-dibenzyl-2,6-dioxo-N-(penta-3,4-dien-1-yl)piperidine-3-carboxamide 
• 1240791-65-4 N-benzyl-2-oxo-N-(penta-3,4-dien-1-yl)cyclooctanecarboxamide 
• 1240791-56-3 N-benzyl-2-oxo-N-(penta-3,4-dien-1-yl)cyclopentanecarboxamide 
• 1240791-70-1 N,N-dibenzyl-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide 
• 1240791-63-2 N-benzyl-2-oxo-N-(penta-3,4-dien-1-yl)cyclohexanecarboxamide 
• 1240791-72-3 N-benzyl-1-methyl-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide 
• 1240791-69-8 tert-butyl 3-[benzyl(penta-3,4-dien-1-yl)carbamoyl]-2-oxopyrrolidine-1-carboxylate 
• 1438394-39-8 methyl 4-{1-[(2R,4'S)-1'-benzyl-1,2'-dioxo-1,3-dihydrospiro[indene-2,3'-piperidin]-4'-yl]vinyl}benzoate 
• 1438394-40-1 (2R,4'S)-1'-benzyl-4'-(1-phenylvinyl)-2'H-spiro[indene-2,3'-piperidine]-1,2'(3H)-dione 
• 1438394-41-2 (2R,4'S)-1'-benzyl-4'-[1-(4-methoxyphenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione 
• 1438394-42-3 (2R,4'S)-1'-benzyl-4'-[1-(3,5-dimethylphenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione 
• 1438394-43-4 methyl 3-{1-[(2R,4'S)-1'-benzyl-1,2'-dioxo-1,3-dihydrospiro[indene-2,3'-piperidin]-4'-yl]vinyl}benzoate 

Relevant academic research and scientific papers

Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades

The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)2 and chiral bis(oxazoline) ligands to afford the spirolactam products in good yields and high enantio- and diastereoselectivities. The Royal Society of Chemistry 2013.

Stereoselective spirolactam synthesis via palladium catalyzed arylative allene carbocyclization cascades

A diastereoselective arylative carbocyclization of pro-nucleophile-linked allenes with aryl and heteroaryl halides to provide spirocyclic lactam products with moderate to high diastereoselectivities and good yields under Pd(0) catalysis is reported. Being operationally simple and tolerant of multiple points of diversity, this complexity building reaction cascade, in which two new carbon-carbon bonds and one new heterocyclic ring are created, should be of high value in both complex natural product synthesis as well as compound library synthesis.