107301-61-1

Basic information

• Product Name: Benzenemethanamine, N-3-butynyl-
• CAS NO: 107301-61-1
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Mol File: 107301-61-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-3-butynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-3-butynyl-(107301-61-1)
• EPA Substance Registry System: Benzenemethanamine, N-3-butynyl-(107301-61-1)

Safety Data

• Hazardous Substances Data: 107301-61-1(Hazardous Substances Data)

Upstream product

• 72486-09-0 methanesulfonic acid but-3-ynyl ester 
• 100-46-9 benzylamine 
• 227030-66-2 (+/-)-1-benzylazetidine-2-carbonitrile 
• 192989-95-0 1-methanesulfonyl-3-butyn 
• 927-74-2 3-Butyn-1-ol 
• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 
• 36832-51-6 1-(but-3-yn-1-ylsulfonyl)-4-methylbenzene 

Downstream Products

• 178392-67-1 2-amino-6-(N-benzyl-N-3-butynylamino)-4-chloro-5-formylpyrimidine 
• 1067676-15-6 dimethyl 2-(N-benzyl-N-(but-3-ynyl)amino)malonate 
• 38025-34-2 4-ethyl-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine 
• 38025-47-7 1,2,3,6-tetrahydro-4-[(1E)-2-phenylethenyl]-1-(phenylmethyl)-pyridine 
• 163630-89-5 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine 
• 821768-11-0 1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-pyridine 
• 912768-64-0 1,2,3,6-tetrahydro-4-(3-methylphenyl)-1-(phenylmethyl)-pyridine 
• 13314-67-5 1,2,3,6-tetrahydro-4-(4-methylphenyl)-1-(phenylmethyl)-pyridine 
• 231958-20-6 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine 
• 13314-69-7 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine 
• 1048976-47-1 1,2,3,6-tetrahydro-4-(3-nitrophenyl)-1-(phenylmethyl)-pyridine 
• 1048976-46-0 4-(4-formylphenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine 
• 32245-93-5 1-[4-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-ethanone 
• 38025-45-5 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine 

Relevant articles and documents

Synthesis of homopropargylamines from 2-cyanoazetidines

2-Cyanoazetidines, easily accessible from β-amino alcohols, undergo ring-cleavage upon reaction with trimethylsilylazide and catalytic amounts of Bu2SnO, to give the corresponding homopropargylamines which are isolated as their N-Boc protected

Iodocarbamation of N-Homopropargyl Carbamates: Mild and Stereoselective Entry to Functionalized Oxazinan-2-ones

An efficient and general iodocarbamation of benzyl N-homopropargylcarbamates has been developed by using iodine as the electrophilic agent. This regio- and stereoselective cyclization yielded (E)-6-iodomethyleneoxazinan-2-ones, which can be further transformed through palladium cross-coupling reactions followed by hydrogenation to produce 1,3-oxazinan-2-ones.

Regioselective Amine–Borane Cyclization: Towards the Synthesis of 1,2-BN-3-Cyclohexene by Copper-Assisted Triazole/Gold Catalysis

The combination of triazole/gold (TA-Au) and Cu(OTf)2is identified as the optimal catalytic system for promoting intramolecular hydroboration for the synthesis of a six-membered cyclic amine–borane. Excellent yields (up to 95 %) and regioselectivities (5-exo vs. 6-endo) were achieved through catalyst control and sequential dilution. Good functional-group tolerance was attained, thus allowing the preparation of highly functionalized cyclic amine–borane substrates, which could not be achieved using other methods. Deuterium-labeling studies support the involvement of a hydride addition to a gold-activated alkyne with subsequent C?B bond formation.