1240847-29-3Relevant academic research and scientific papers
Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group
Nishida, Yuika,Takeda, Norihiko,Matsuno, Kenji,Miyata, Okiko,Ueda, Masafumi
, p. 3928 - 3935 (2018)
Chloroform-mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the presence of air, the three-component aminocarbonylation reaction proceeded via in-situ generation of phosgene from chloroform and O2 to provide indole-3-carboxamides in a single operation. Application to the synthesis of biologically active compounds and intramolecular acylation are also described.
Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides
Xing, Qi,Shi, Lijun,Lang, Rui,Xia, Chungu,Li, Fuwei
supporting information, p. 11023 - 11025 (2013/01/15)
A novel and efficient double-carbonylation of indoles with primary or secondary amines to yield indole-3-α-ketoamides has been developed and bioactive molecules could be one-pot synthesized using the current methodology, which could also be selectively switched to mono-carbonylation to afford indole-3-amides only by a slight modification of reaction conditions.
