1240949-53-4Relevant academic research and scientific papers
An Efficient, Scalable and Eco-friendly Synthesis of 4,5-substituted Pyrrole-3-Carbonitriles by Intramolecular Annulation on Pd/C and HZSM-5
Chen, Jianchao,Li, Chengtao,Zhou, Yanan,Sun, Changshan,Sun, Tiemin
, p. 1943 - 1948 (2019/03/26)
An efficient and eco-friendly protocol for the synthesis of diverse 4,5-substituted 1H-pyrrole-3-carbonitriles has been developed using commercially available HZSM-5 and Pd/C as recyclable heterogeneous catalysts with more excellent yields (up to 98 %) than traditional liquids acids, and successfully applied in the practical synthesis of vonoprazan. The conspicuous features of this protocol are higher product yield, easy work-up, eco-friendly and reusability of catalysts.
PROCESS FOR PRODUCING PYRROLE COMPOUND
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Page/Page column 38, (2012/01/03)
The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of produci
