26454-81-9

Usage

Malononitrile derivative

Contains two cyano groups (-CN) bound to a central carbon atom.

4-chlorophenyl group

A chlorine atom attached to a phenyl ring at the 4-position.

2-oxoethyl group

An ethyl group with an oxygen atom double-bonded to a carbon atom (C=O).

Applications in organic synthesis

Used in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals.

Intermediate in production

Serves as an intermediate in the production of dyes, pigments, and other specialty chemicals.

Versatile compound

Has diverse applications in the chemical industry.

Use in new material development

Can be used in the development of new materials.

Research and development

Utilized in research and development processes.

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 109-77-3 malononitrile 

Downstream Products

• 125041-29-4 5-Amino-3-(4-chloro-benzoyl)-1-phenyl-1H-pyrazole-4-carbonitrile 
• 144294-76-8 C₂₂H₁₂Cl₂N₄S₂ 
• 26454-85-3 2-amino-5-(4'-chlorophenyl)furan-3-carbonitrile 
• 125041-30-7 1-(4-Chloro-phenyl)-2-(3,5-diamino-1H-pyrazol-4-yl)-ethanone 
• 125041-31-8 1-(4-Chloro-phenyl)-2-(3,5-diamino-1-phenyl-1H-pyrazol-4-yl)-ethanone 
• 22109-05-3 2-Amino-5-p-chlorophenyl-4,5-dihydro-3-cyanofuran 
• 744255-24-1 6-(4-chloro-phenyl)-furo[2,3-d]pyrimidin-4-ylamine 
• 132171-97-2 2-p-Chlorophenyl-1-cyanocyclopropanecarboxamide 
• 125041-38-5 Pyrazolo<3,4-d>pyridazine 
• 125041-36-3 Pyrazolo<3,4-d>pyrimidine 
• 125041-35-2 Pyrazolo<3,4-d>pyrimidinone 
• 125041-37-4 Pyrazolo<3,4-d>pyrimidine 
• 1240949-53-4 5-(4-chlorophenyl)-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

Copper-Catalyzed Tandem Dehydrocyanation and [3+2] Cyclo-addition Reactions of Phenacylmalononitriles: Regioselective Synthesis of Functionalized 4-Benzoyl-5-cyanopyrazoles under Mild Conditions

A novel copper-catalyzed [3+2] cycloaddition reaction with concomitant in situ generation of benzoylacrylonitriles and nitrile imines from phenacylmalononitriles and hydrazonoyl chlorides, respectively, is reported. The reaction was performed using copper(I) chloride as catalyst and N-methylimidazole as a clean complexing agent/weak base to afford the functionalized 4-benzoyl-5-cyanopyrazoles in moderate to good yields and excellent regioselectivity under ambient conditions. This method provides rapid access to a wide range of highly functionalized 4-benzoyl-5-cyanopyrazoles.

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

One-Step, Effective, and Cascade Syntheses of Highly Functionalized Cyclopentenes with High Diastereoselectivity

Tetrabutylammonium fluoride works as an effective organocatalyst for the cycloaddition between phenacylmalononitriles and electron-deficient olefins (having substituent groups of NO2, CHO, and COR), providing a facile synthetic route to versatile multifunctionalized cyclopentenes having an allylic quaternary carbon center bearing both cyano and carboxamide groups with high yields and high diastereoselectivity. Preliminary studies reveal that these functionalized cyclopentenes are convenient precursors for making α-cyano-functionalized cyclopentadienone oximes.

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and selective glycogen synthase kinase-3 inhibitors

Modeling studies of a furo[2,3-d]pyrimidine GSK-3 hit compound 1 superimposed onto the X-ray crystal structure of a legacy pyrazolo[3,4-c] pyridazine GSK-3 inhibitor 2 led to the identification of 4-acylamino-6- arylfuro[2,3-d]pyrimidine template 3. Synth

New Syntheses of Pyrazolopyrimidine, Pyrazolopyridazine, Isoindolinedione and Pyrazole Derivatives

Phenacylmalononitriles 2 react with hydrazines, acetic-hydrochloric acid and with diazotised primary aromatic amines to afford phenacylpyrazole (5a,b), aminofurans (6a,b) and aminopyrazole derivatives (3a,d) respectively.The synthesised derivatives (3d,6a