1241038-97-0Relevant academic research and scientific papers
1,1-dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles
Pacheco Berciano, Beatriz,Lebrequier, Sabrina,Besselievre, Francois,Piguel, Sandrine
supporting information; experimental part, p. 4038 - 4041 (2010/11/16)
The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.
Copper as a powerful catalyst in the direct alkynylation of azoles
Besselievre, Francois,Piguel, Sandrine
experimental part, p. 9553 - 9556 (2010/03/25)
[Chemical equation presented] Copper-bottomed catalysis! The direct alkynylation of azoles through a copper-based C - H bond activation, using alkynylbromides as the coupling partner, has been developed (see scheme). The method is very rapid, is functional-group tolerant, and provides a straightforward entry to diverse alkynyl heterocycles that is complementry to the Sonogashira reaction.
