54075-68-2Relevant academic research and scientific papers
Csp-Csp3 Bond Formation via Iron(III)-Promoted Hydroalkynylation of Unactivated Alkenes
Shen, Yangyong,Huang, Bo,Zheng, Jing,Lin, Chen,Liu, Yu,Cui, Sunliang
supporting information, p. 1744 - 1747 (2017/04/11)
An iron(III)-promoted hydroalkynylation of unactivated alkenes toward Csp-Csp3 bond formation has been developed. Various alkenes, including mono-, di-, and trisubstituted alkenes, could all smoothly convert to structural diversified alkynes in this chemoselective protocol. Additionally, the scalability was unraveled and the further divergent transformations of products were conducted to demonstrate the synthetic utility.
Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles
Zhu, Lei,Yu, Yinghua,Mao, Zhifeng,Huang, Xueliang
supporting information, p. 30 - 33 (2015/07/28)
(Chemical Equation Presented). An effective gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions and gives the polysubstituted pyrroles in good-to-excellent yields. Preliminary results indicate that a nongold carbenoid pathway is preferred for current pyrrole synthesis.
Copper catalyzed decarboxylative alkynylation of quaternary α-cyano acetate salts
Feng, Yi-Si,Xu, Zhong-Qiu,Mao, Long,Zhang, Feng-Feng,Xu, Hua-Jian
supporting information, p. 1472 - 1475 (2013/06/27)
Cu-catalyzed decarboxylative alkynylation of quaternary α-cyano acetate salts with alkynyl bromides and alkynyl chlorides is described. This new reaction can be used for preparing functionalized butynenitrile derivatives.
Intramolecular carbocupration of N-aryl-ynamides: A modular indole synthesis
Gati, Wafa,Couty, Francois,Boubaker, Taoufik,Rammah, Mohamed M.,Rammah, Mohamed B.,Evano, Gwilherm
supporting information, p. 3122 - 3125 (2013/07/26)
A modular indole synthesis based on an intramolecular 5-endo-dig carbocupration starting from readily available N-aryl-ynamides is reported. A variety of ynamides are converted to indoles in moderate to good yields and with varying substitution pattern on the indole ring. This further extends the synthetic utility of ynamides in organic synthesis and provides additional insights on the use of intramolecular carbometalation reactions.
