1241412-95-2Relevant academic research and scientific papers
Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines
Kaura, Mamta,Kumar, Pawan,Hrdlicka, Patrick J.
, p. 8575 - 8578 (2012)
Oligonucleotides modified with consecutive incorporations of 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridine monomers X-Z display strong thermal affinity and binding specificity toward RNA targets, due to formation of chromophore arrays in the major groove.
Pyrene-functionalized triazole-linked 2′-deoxyuridines - Probes for discrimination of single nucleotide polymorphisms (SNPs)
stergaard, Michael E.,Guenther, Dale C.,Kumar, Pawan,Baral, Bharat,Deobald, Lee,Paszczynski, Andrzej J.,Sharma, Pawan K.,Hrdlicka, Patrick J.
supporting information; experimental part, p. 4929 - 4931 (2010/08/20)
Oligonucleotides modified with pyrene-functionalized triazole-linked 2′-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.
