124154-95-6Relevant academic research and scientific papers
TRANSITION METAL COMPLEXES OF AMINO ACIDS AND RELATED LIGANDS AND THEIR USE AS CATALYSTS, ANTI-MICROBIALS, AND ANTI-CANCER AGENTS
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Paragraph 0161; 0162; 0163; 0164, (2013/04/24)
The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.
Metal Complexes of Biologically Important Ligands, LIII - Chiral Half-Sandwich Complexes of Rhodium(III), Iridium(III), Iridium(I) and Ruthenium(II) with α-Amino Acid Anions
Kraemer, Roland,Polborn, Kurt,Wanjek, Herbert,Zahn, Ingo,Beck, Wolfgang
, p. 767 - 778 (2007/10/02)
The chloro-bridged metal compounds Cp*(Cl)M(μ-Cl)2M(Cl)Cp* (M = Rh, Ir; Cp* = η5-C5Me5), (η6-C6H6)(Cl)Ru(μ-Cl)2Ru(Cl)(η6-C6H6), and (COD)Ir(μ-Cl)2Ir(COD) react with α-amino acidates to give monomeric chelate complexes Cp*(Cl)M(L-L') (1) (M = Rh, Ir; L-L' = GlyO, L-ValO, L-PheO, PhenylglyO, L-TrpO, L-ProO, L-HisO, L-AspO, L-azetidine-2-carboxylate), Cp*M(L-AspO,O') (2) (M = Rh, Ir), *(Cl)Ir(L-HisOH)>+Cl- (3), (η6-C6H6)(Cl)Ru(L-L') (4) (L-L' = L-ProO, L-PheO, L-p-NO2PheO, L-DopaO, D-PhenylglyO), 6-C6H6)Ru(L-HisO)>+Cl- (5), and(COD)Ir(L-L') (7, 8) (L-L' = L-AlaO, L-PheO, L-ValO, L-LeuO, L-PhenylglyO, L-1-aminocyclopropanecarboxylate), respectively.The complexes 1-5 have a stereogenic metal atom.Similarly, the cleavage of chloro bridges in (COD)Ir(μ-Cl)2Ir(COD) by α-amino acid esters affords the complexes (COD)(Ir(Cl)L (6) (L = GlyOEt, L-AlaOMe, L-ValOMe).The diastereoisomers of 1, 3, and 4 can be detected by NMR spectroscopy.With prolinate a diastereoselectivity up to 92:8 is archieved.The structures of Cp*(Cl)Ir(L-ProO) (1j), Cp*(Cl)Rh(L-azetidine-2-carboxylate) (1m), *(Cl)Ir(L-HisOH)>Cl (3), and (η-C6H6)(Cl)Ru(L-ProO) (4a) have been determined by X-ray crystallography.
