1241680-48-7

Upstream product

• 132153-48-1 N-(tert-Butyloxycarbonyl)-4-bromo-DL-phenylalanine 
• 14091-15-7 p-bromo-DL-phenylalanine 
• 132067-41-5 methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate 
• 943148-41-2 (S)-2-tert-butoxycarbonylamino-3-[4-(diethoxy-phosphoryl)-phenyl]-propionic acid ethyl ester 
• 103882-09-3 N-Boc-4-I-Phe-OH 
• 943148-40-1 (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 71078-92-7 diethyl (acetylamino)<(4-bromophenyl)methyl>propanedioate 
• 120667-47-2 diethyl (acetylamino)<<4-(diethoxyphosphinyl)phenyl>methyl>propanedioate 
• 132067-42-6 N-(tert-Butyloxycarbonyl)-4-(diethoxyphosphono)-DL-phenylalanine methyl ester 

Relevant academic research and scientific papers

Efficient synthesis of protected l-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis

l-Phosphonophenylalanine (Ppa) derivatives were synthesized from l-4-iodophenylalanine and suitably protected phosphites using Michaelis-Arbuzov reaction conditions in the presence of Pd(0) and triethylamine at 70 ± 2 °C.

Synthesis of 4-phosphono- and of 4-(phosphonomethyl)-dl-phenylalanine, two analogues of O-phosphotyrosine

:4-Phosphono-DL-phenylalanine 1 was synthetized from 4-bromo-DL-phenylalanine or from 4-(bromomethyl)-bromobenzene ; 4-(phosphonomethyl)-DL-phenylalanine 14 was prepared from methyl p-toluate. The interest of these phosphonic analogues arises from their possible interference in the metabolism of O-phosphotyrosine.

Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists

To investigate the preferred spatial relationship of the distal phosphonic acid to the α-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-