1241682-42-7

Basic information

• Product Name: (R)-1-(3',4',5'-trimethoxyphenyl)ethylamine
• CAS NO: 1241682-42-7
• Molecular Weight: 211.261
• Mol File: 1241682-42-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(3',4',5'-trimethoxyphenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3',4',5'-trimethoxyphenyl)ethylamine(1241682-42-7)
• EPA Substance Registry System: (R)-1-(3',4',5'-trimethoxyphenyl)ethylamine(1241682-42-7)

Safety Data

• Hazardous Substances Data: 1241682-42-7(Hazardous Substances Data)

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 122078-21-1 (1S,1'S)-N-(1'-phenylethyl)-1-(3'',4''.5''-trimethoxyphenyl)ethylamine 

Relevant articles and documents

Chiral Building Blocks for the Synthesis of Nitrogen-Containing Natural Products, 5. The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones

An efficient two-step procedure for the synthesis of enantiomerically pure, benzene nucleus-substituted 1-phenylethylamines 1 is described, with predictable absolute configuration at the stereogenic center: Imine formation from the substituted acetophenones 6 with (S)- or (R)-1-phenylethylamine and subsequent hydrogenation of the resulting Schiff bases 8 over Raney nickel leads to the secondary amines 9 and 10 in high diastereoselectivities.These dibenzylamines are cleaved regioselectively, usually next to the less substituted aromatic ring, giving the desired chiral 1-phenylethylamines 1 in high yields and enantiomeric purities.Scope and limitations of this new and facile approach to the versatile building blocks 1 are reported.