1241735-36-3Relevant academic research and scientific papers
Enantioselective reductive aldol reaction using tertiary amine as hydride donor
Osakama, Kazuki,Sugiura, Masaharu,Nakajima, Makoto,Kotani, Shunsuke
supporting information; experimental part, p. 4199 - 4201 (2012/08/28)
An efficient method was developed for the enantioselective reductive aldol reaction of α,β-unsaturated ketones with aldehydes in the presence of a Lewis base catalyst; conjugate reduction using a tertiary amine and trichlorosilyl triflate, followed by an aldol reaction with BINAP dioxide (BINAPO) as an organocatalyst, gave the corresponding product in high yield with high stereoselectivity.
Diastereo- and enantioselective reductive aldol reaction with trichlorosilane using Chiral Lewis bases as organocatalysts
Sugiura, Masaharu,Sato, Norimasa,Sonoda, Yuko,Kotani, Shunsuke,Nakajima, Makoto
supporting information; experimental part, p. 478 - 481 (2010/09/04)
Chiral Lewis base organocatalysts activate trichlorosilane to promote the tandem conjugate reduction/aldol reaction of α, β-unsaturated ketones with aldehydes to give optically active β-hydroxy ketones with good to high syn diastereo- and enantioselectivi
