1241794-84-2Relevant academic research and scientific papers
Phase-transfer-catalyzed asymmetric alkylation of a-benzoyloxy-b-keto esters: Stereoselective construction of congested 2, 3-dihydroxycarboxylic acid esters
Hashimoto, Takuya,Sasaki, Keigo,Fukumoto, Kazuhiro,Murase, Yuichi,Abe, Naoyuki,Ooi, Takashi,Maruoka, Keiji
supporting information; experimental part, p. 562 - 570 (2010/08/19)
Highly enantioselective phase-transfer-catalyzed alkylation of tert-butyl 2-benzoyloxy-3-oxobutanoate was realized by the use of an N-spiro chiral quaternary ammonium salt, as a complementary approach to the asymmetric hydroxylation of α-alkyl-β-keto esters. The synthetic utility of the alkylated compounds is highlighted by the diastereoselective reduction and alkylation of the remaining ketone moiety to give various enantiomerically enriched congested 2, 3-dihydroxycarboxylic acid esters.
