1241896-14-9

Upstream product

• 15647-86-6 triethylphosphine hydrobromide 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 104737-98-6 (1E,3E)-1-methoxy-1,4-diphenylbuta-1,3-diene 
• 1241896-28-5 (E)-1-methoxy-1-phenyl-2-(3,4-methylenedioxyphenyl)ethene 
• 1241896-29-6 (E)-1-methoxy-1-phenyl-2-(p-fluorophenyl)ethene 
• 1241896-27-4 (E)-1-methoxy-1-phenyl-2-(p-chlorophenyl)ethene 
• 1241896-24-1 (E)-1-methoxy-1-phenyl-2-(p-nitrophenyl)ethene 
• 19191-03-8 (E)-1-methoxy-1,2-diphenylethene 
• 19202-54-1 (Z)-1-methoxy-1,2-diphenylethene 
• 1241896-26-3 (E)-1-methoxy-1-phenyl-2-(o-fluorophenyl)ethene 
• 72050-17-0 (E)-ethyl 3-methoxy-3-phenylacrylate 
• 72050-18-1 ethyl 3-methoxy-3-phenyl-2(Z)-propenoate 

Relevant academic research and scientific papers

Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)

Synthesis of a novel class of natural product inspired cinnamyl-containing 1,4,5-triazole and the potent inhibition of human aromatase (CYP 450 19A1) by select members is described. Structure-activity data generated provides insights into the requirements for potency particularly the inclusion of an aryl bromide or chloride residue as a keto-bioisostere.

Dichotomous reactivity in the reaction of triethyl- and triphenylphosphane HBr salts with dimethyl acetals: A novel entry to α-alkoxy-functionalized ylides and general synthesis of vinyl ethers and alkoxy dienes

The discovery of dichotomous reactivity in the reaction of trialkyl- vs. triphenylphosphane HBr salts with acetals allows entry to functionalized α-methoxy phosphonium salts and a novel process for tertiary phosphane methylation. The new protocol opens a general entry to the synthesis of vinyl ethers and differentially substituted 1,3-dienes via Wittig reactions of the functionalized ylides derived from the α-methoxy phosphonium salts.