72050-17-0Relevant academic research and scientific papers
Chromium-copper exchange of Fischer carbene complexes: X-ray crystal structure of a [Cu{=CR1(OR2)}(MeCN)(Et2O)][PF6] complex
Barluenga, Jose,Lopez, Luis A.,Loeber, Oliver,Tomas, Miguel,Garca-Granda, Santiago,Alvarez-Ra, Carmen,Borge, Javier
, p. 3392 - 3394 (2001)
The chromium-copper interaction is evidenced for chromium-carbene complexes and Cu+ in the CuBr-catalyzed cross-coupling reaction of ethyl diazoacetate (EDA) and Fischer alkoxycarbene - chromium complexes (see scheme). In contrast, with [Cu(MeCN)4][PF6] (0.5 equiv) instead of CuBr a carbene ligand exchange between a chiral alkenylchromium carbene complex (R1 = (E) CH=CH-2-furyl, R2 = (1R, 2S, 5R)-menthyl) and this Cu compound occurs at room temperature. The resulting novel trigonal-planar copper(I) - carbene complex, which contains MeCN and Et2O as the remaining ligands, has been isolated and structurally characterized by X-ray diffraction.
Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication
Kozlov,Kleymenova,Konduktorov,Malikova,Kamarova,Novikov,Kochetkov
, p. 191 - 197 (2016/04/19)
According to recently published results, cinnamic hydroxamic acid (CHA) inhibits replication of hepatitis C virus (HCV). We synthesized a structural analogue of CHA, i.e., (Z)-N-hydroxy-3-methoxy3-phenylacrylamide, which inhibited HCV replication five tim
Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)
McNulty, James,Keskar, Kunal,Crankshaw, Denis J.,Holloway, Alison C.
supporting information, p. 4586 - 4589 (2015/02/06)
Synthesis of a novel class of natural product inspired cinnamyl-containing 1,4,5-triazole and the potent inhibition of human aromatase (CYP 450 19A1) by select members is described. Structure-activity data generated provides insights into the requirements for potency particularly the inclusion of an aryl bromide or chloride residue as a keto-bioisostere.
Structure-activity studies of a series of dipyrazolo[3,4-b:3′,4′-d]pyridin-3-ones binding to the immune regulatory protein B7.1
Green, Neal J.,Xiang, Jason,Chen, Jing,Chen, Lihren,Davies, Audrey M.,Erbe, Dave,Tam, Steve,Tobin, James F.
, p. 2991 - 3013 (2007/10/03)
The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. To this end, specific small molecule inhibitors of human B7.1 were identified and characterized. Herein, we report the identification of potent small molecule inhibitors of the B7.1-CD28 interaction. In a high-throughput screen we identified several leads that prevented the interaction of B7.1 with CD28 with activities in the nanomolar to low micromolar range. One of these, the dihydrodipyrazolopyridinone 1, was subsequently shown to bind the V-like domain of human B7.1 at equimolar stoichiometry. With this as a starting point, we report here the synthesis and initial in vitro structure-activity relationships of a series of these compounds.
MESOMERIC ANIONS. X. METHYLATION OF ALKALI-METAL DERIVATIVES OF SOME 1,3-KETONITRILES
Emelina, E. E.,Ershov, B. A.
, p. 692 - 696 (2007/10/02)
The effect of polar factors on the relative nucleophilicity of the oxygen and carbon reaction centers in the alkali-metal derivatives of 2-(X-benzoyl)acetonitriles, 2-(X-benzoyl)propionitriles, and 2-(X-phenyl)acetylacetonitriles was investigated.During methylation with methyl iodide and methyl p-toluenesulfonate in DMFA the ratio of the C- and O-methylation products for all the investigated compounds decreases with increase in the accepting power of the substituent X.It was shown that the sensitivity of the C-reaction center to the effect of the substituent X is greater than that of the O-center.
