1241899-80-8

Upstream product

• 331984-42-0 2-(benzo[d]thiazol-2-ylsulfonyl)-1-phenylethan-1-one 
• 70-11-1 α-bromoacetophenone 
• 149-30-4 2-Mercaptobenzothiazole 
• 1610-04-4 α-bromo-α,α-difluoro-acetophenone 

Downstream Products

• 1254083-91-4 (4,4-difluorobut-3-en-1-yne-1,3-diyl)dibenzene 
• 852561-60-5 ethyl 3-phenyl-4,4-difluoro-3-butenoate 
• 1254083-98-1 C₁₃H₁₄F₂Si 

Relevant academic research and scientific papers

CF2DSO2Na: An Effective Precursor Reagent for Deuteriodifluoromethylthiolation and Deuteriodifluoromethylation

Deuteriodifluoromethythio (SCF2D) and deuteriodifluoromethyl (CF2D) are important functional groups in pharmaceutical and agrochemical compounds, and the introduction of these functional groups remains a challenging. We herein report a robust reagent for deuteriodifluoromethylthiolation and deuteriodifluoromethylation. Its potentials were successfully showcased by deuteriodifluoromethylation and deuteriodifluoromethylthiolation of indoles with high-level deuterium incorporation. The reagent also has potential for deuteriodifluoromethylation and deuteriodifluoromethylthiolation of wide range of other natural or synthetic bioactive molecules.

An efficient method for the synthesis of gem-difluoroolefins

A series of gem-difluoroolefin derivatives were synthesized in moderate to good yields by the reaction of α,α-difluoro-β-carbonyl benzothiazol-2-yl sulfones (DFBTs) with various carbon nucleophiles. Using dl-proline as organocatalyst, the reaction of DFBT with acetone gave a tertiary alcohol, which could be further converted to the corresponding difluoroolefin by LDA.

Synthesis of difluorinated β-ketosulfones and novel gem-difluoromethylsulfone-containing heterocycles as fluorinated building blocks

A series of new heterocyclic β-ketosulfides was prepared by the reaction of the corresponding heterocyclic thiols with α-bromoacetophenone and its derivatives. Oxidation of the products using m-CPBA gave the corresponding heterocyclic β-ketosulfones, whic