1254083-91-4

Upstream product

• 1010720-48-5 tributyl-(β,β-difluoro-α-phenylvinyl)-stannane 
• 932-88-7 1-iodo-2-phenylethyne 
• 960-16-7 tributylphenylstannane 
• 3757-88-8 tributylstannylethynylbenzene 
• 1610-04-4 α-bromo-α,α-difluoro-acetophenone 
• 13652-11-4 2,2,2‐trifluoro‐1‐phenylethan‐1‐one tosylhydrazone 
• 536-74-3 phenylacetylene 
• 622-79-7 benzyl azide 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 98-80-6 phenylboronic acid 
• 1241899-80-8 α,α-difluoro-β-carbonyl benzothiazol-2-yl sulfone 

Relevant academic research and scientific papers

Cu(I)-Catalyzed Three-Component Coupling of Trifluoromethyl KetoneN-Tosylhydrazones, Alkynes and Azides: Synthesis of Difluoromethylene Substituted 1,2,3-Triazoles

A CuI-catalyzed three-component coupling of trifluoromethyl ketone N-tosylhydrazones, alkynes and azides has been developed. The reactionrepresents a straightforward method to access difluoromethylene substituted 1,2,3-triazoles. Mechanistically, it has been proposed that the reaction follows a pathway involving the formation of Cu(I)triazolide intermediate, Cu(I) carbene formation, migratory insertion, and β-fluoride elimination. Thetransformation is featured by mild conditions, wide substrate scope and high efficiency.

Synthesis of 2-aryl-1,1-difluoro-1,3-enynes via consecutive cross-coupling reactions of 2,2-difluoro-1-iodoethenyl p-toluenesulfonate

Alkynylation reaction of 2,2-difluoro-1-iodoethenyl p-toluenesulfonate 1 with alkynyltributylstannanes in the presence of 10 mol% Pd(PPh3)4 and 10 mol% CuI in THF at reflux temperature for 3 h provided the corresponding 1,1-difluoro-

Cross-coupling of 1,1-difluoro-1-en-3-yn-2-yl tosylates with arylboronic acids: A new approach to 2-aryl-1,1-difluoro-1,3-enynes

The palladium-catalyzed direct alkynylation of 2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate 1 with alkynyl bromides provided the corresponding 1,1-difluoro-1,3-enynyl tosylates 2 in good yields. The Suzuki-Miyaura arylation reaction of 2 with arylboronic acids afforded the cross-coupled products, 2-aryl-1,1-difluoro-1,3-enynes 3, in good yields.

An efficient method for the synthesis of gem-difluoroolefins

A series of gem-difluoroolefin derivatives were synthesized in moderate to good yields by the reaction of α,α-difluoro-β-carbonyl benzothiazol-2-yl sulfones (DFBTs) with various carbon nucleophiles. Using dl-proline as organocatalyst, the reaction of DFBT with acetone gave a tertiary alcohol, which could be further converted to the corresponding difluoroolefin by LDA.

A 1, 1 - difluoro - 1, 3 - enynes synthetic method of the compound

The invention discloses a synthetic method of 1, 1-2 fluorine - 1, 3 - acetylene compounds. The synthetic method enable tosylhydrazones and acetylene compounds of Alpha, alpha, alpha, 3 methyl ketone to react in organic solvent. 1, 1-2 fluorine - 1, 3 - a

Cu(I)-Catalyzed Cross-Coupling of Terminal Alkynes with Trifluoromethyl Ketone N-Tosylhydrazones: Access to 1,1-Difluoro-1,3-enynes

C-C Bond formation and β-F elimination have been achieved in a Cu(I)-catalyzed cross-coupling reaction of terminal alkynes and trifluoromethyl ketone N-tosylhydrazones. The reaction represents an efficient synthesis of 1,1-difluoro-1,3-enyne derivatives.