1241946-89-3

Basic information

• Product Name: Simeprevir sodium
• Synonyms: Simeprevir sodium;TMC 435 sodium salt
• CAS NO: 1241946-89-3
• Molecular Formula: C38H47N5O7S2.x(Na)
• Molecular Weight: 773.94
• EINECS: -0
• Mol File: 1241946-89-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Simeprevir sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Simeprevir sodium(1241946-89-3)
• EPA Substance Registry System: Simeprevir sodium(1241946-89-3)

Safety Data

• Hazardous Substances Data: 1241946-89-3(Hazardous Substances Data)

Usage

Description

Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.