1241956-47-7Relevant academic research and scientific papers
Copper-catalyzed three-component synthesis of 2-iminodihydrocoumarins and 2-iminocoumarins
Shen, Yang,Cui, Sunliang,Wang, Jing,Chen, Xiaopeng,Lu, Ping,Wang, Yanguang
supporting information; scheme or table, p. 1139 - 1144 (2010/06/20)
An efficient synthesis of N-sulfonyl-substituted 2-imino-3,4- dihydrocoumarins and 2-iminocoumarins via a copper-catalyzed multicomponent reaction of sulfonyl azides with terminal alkynes and β-(ortho- hydroxyphenyl)-α β-unsaturated ketones or ortho- hydroxyphenylpropiolates has been developed. The cascade process involves trapping the keteimine by a nucleophilic addition and an intramolecular Michael addition. This methodology could well be extended to the concise synthesis of the polysubstituted piperidine scaffold.
