425686-45-9

Upstream product

• 1002130-71-3 methyl 3-[2-(methoxymethoxy)phenyl]propiolate 
• 533-58-4 2-Iodophenol 

Downstream Products

• 20280-81-3 4-methoxycoumarin 
• 15185-05-4 4-phenylcoumarin 
• 1241956-41-1 C₂₄H₁₉NO₅S 
• 1241956-51-3 C₂₅H₂₀N₂O₈S 
• 1241956-47-7 C₂₆H₂₂N₂O₆S 
• 1241956-48-8 C₁₉H₁₇NO₅S 
• 1417564-37-4 C₁₈H₁₆O₄ 
• 1417564-38-5 C₁₇H₁₄O₄ 
• 1417564-39-6 C₁₈H₁₆O₅ 
• 1417564-40-9 C₁₉H₁₉NO₄ 
• 1417564-41-0 C₁₇H₁₃FO₄ 
• 1417564-51-2 methyl 2-(4-chlorophenyl)-4-hydroxy-2H-chromene-3-carboxylate 
• 1417564-52-3 methyl 2-(4-bromophenyl)-4-hydroxy-2H-chromene-3-carboxylate 
• 1417564-53-4 methyl 4-hydroxy-2-(4-nitrophenyl)-2H-chromene-3-carboxylate 

Relevant academic research and scientific papers

Studies toward the Total Synthesis of Arylnaphthalene Lignans via a Photo-Dehydro-Diels-Alder (PDDA) Reaction

An efficient method for the preparation of arylnaphthalene lignans (ANLs) was developed, which is based on the Photo-Dehydro-Diels-Alder (PDDA) reaction. While intermolecular PDDA reactions turned out to be inefficient, the intramolecular variant using suberic acid as tether linking two aryl propiolic esters smoothly provided naphthalenophanes. The irradiations were performed with a previously developed annular continuous-flow reactor and UVB lamps. In this way, the natural products Alashinol D, Taiwanin C, and an unnamed ANL could be prepared.

Synthesis of 4-arylcoumarins via Cu-catalyzed hydroarylation with arylboronic acids

(Chemical Equation Presented) In the presence of 2-4 mol % of CuOAc, methyl phenylpropiolates having a MOM-protected hydroxy group at the ortho position underwent hydroarylation with various arylboronic acids in MeOH at ambient temperature, resulting in the formation of 4-arylcoumarins in high yields after the acidic workup. This method was effectively used for the synthesis of biologically active natural and artificial compounds.