1242061-65-9Relevant academic research and scientific papers
A Copper-Catalyzed Decarboxylative Amination/Hydroamination Sequence: Switchable Synthesis of Functionalized Indoles
Li, Tian -Ren,Cheng, Bei -Yi,Wang, Ya -Ni,Zhang, Mao -Mao,Lu, Liang -Qiu,Xiao, Wen -Jing
, p. 12422 - 12426 (2016)
A copper-catalyzed decarboxylative amination/hydroamination sequence of propargylic carbamates with various nucleophiles is described for the first time. It features an earth-abundant metal catalyst, mild reaction conditions, and high efficiency. Further treatments of the resultant key intermediates using an acid or a base in one pot enable the controllable and divergent synthesis of two types of functionalized indoles. Moreover, experiments to demonstrate the synthetic potential of this methodology are performed.
Efficient and general synthesis of 3-aminoindolines and 3-aminoindoles via copper-catalyzed three-component coupling reaction
Chernyak, Dmitri,Chernyak, Natalia,Gevorgyan, Vladimir
supporting information; experimental part, p. 961 - 966 (2010/07/13)
An efficient three-component coupling (TCC) reaction toward a variety of 3-aminoindoline and 3-aminoindole derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction between 2-aminobenzaldehyde, a secondary amine, and an alkyne leading to a propargylamine intermediate which, under the reaction conditions, undergoes cyclization into the indoline core. The latter, upon treatment with a base, smoothly isomerizes into the indole. Alternatively, the indole can directly be synthesized in a one-pot sequential reaction.
