1242156-61-1

Basic information

• Product Name: 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one
• Synonyms: 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one
• CAS NO: 1242156-61-1
• Molecular Weight: 360.816
• Mol File: 1242156-61-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one(1242156-61-1)
• EPA Substance Registry System: 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one(1242156-61-1)

Safety Data

• Hazardous Substances Data: 1242156-61-1(Hazardous Substances Data)

Upstream product

• 1242156-60-0 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 1242156-58-6 4-tert-Butyl-2-dimethoxymethyl-6-fluoro-benzoic acid 
• 1242156-57-5 1-tert-Butyl-3-dimethoxymethyl-5-fluoro-benzene 
• 1123172-37-1 3-tert-butyl-5-fluoro-benzaldehyde 
• 1123172-38-2 1-bromo-3-(tert-butyl)-5-fluorobenzene 
• 1242156-59-7 6-(tert-butyl)-8-fluorophthalazin-1(2H)-one 
• 1433849-07-0 5-(tert-butyl)-7-fluoro-3-methoxyisobenzofuran-1(3H)-one 
• 1242157-09-0 2-(4-tert-butyl-2-1,3-dioxinan-2-yl-6-fluoro-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 1242157-08-9 2-(4-(tert-butyl)-2-(1,3-dioxan-2-yl)phenyl)-4,4-dimethyl-4,5-dihydrooxazole 
• 1242157-07-8 5-tert-butyl-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-benzaldehyde 
• 150943-13-8 2-(4-tert-butyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 438481-01-7 4-(tert-butyl)-N-(1-hydroxy-2-methylpropan-2-yl)benzamide 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Downstream Products

• 1242156-25-7 6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-2H-phthalazin-1-one 
• 1242156-24-6 6-tert-butyl-8-fluoro-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)phthalazin-1(2H)-one 
• 1242157-74-9 6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one 
• 1242157-24-9 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzyl acetate 
• 1242156-76-8 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 1413063-88-3 7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbaldehyde 
• 1413063-93-0 6-tert-butyl-2-[3-chloro-2-(hydroxymethyl)phenyl]-8-(hydroxymethyl)phthalazin-1(2H)-one 
• 1413061-25-2 4-[3-(6-tert-butyl-8-hydroxymethyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide 
• 1413063-83-8 7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile 

Relevant articles and documents

INHIBITORS OF BRUTON'S TYROSINE KINASE

The disclosure includes compounds of Formula (I), wherein R0, R1, R2, R3, R4, R5, and L are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS

8-Fluorophthalazin-1(2h)-one compounds of Formula II where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula II for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.