6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

Base Information

Chemical Name:6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one
CAS No.:1242156-61-1
Molecular Formula:C₁₉H₁₈ClFN₂O₂
Molecular Weight:360.816
Hs Code.:

Synonyms:6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

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Chemical Property of 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

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Technology Process of 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

There total 15 articles about 6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1242156-60-0
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

: 1242156-61-1
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

Guidance literature:: With sodium tetrahydroborate; isopropyl alcohol; In dichloromethane; at 4 - 20 ℃; for 0.5h;

Reference yield:

: 1242156-59-7
6-(tert-butyl)-8-fluorophthalazin-1(2H)-one

: 1242156-61-1
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl trimethylsilyl ether; caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

2: sodium tetrahydroborate; isopropyl alcohol / dichloromethane / 0.5 h / 4 - 20 °C

With sodium tetrahydroborate; ethyl trimethylsilyl ether; caesium carbonate; isopropyl alcohol; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 438481-01-7
4-(tert-butyl)-N-(1-hydroxy-2-methylpropan-2-yl)benzamide

: 1242156-61-1
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 1 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 - -20 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C

3.1: pyridinium p-toluenesulfonate / toluene / Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - -17 °C / Inert atmosphere

4.2: 1.5 h / -78 - 20 °C

5.1: sulfuric acid / methanol; water / Reflux

6.1: hydrazine hydrate / acetic acid / 1.5 h / 50 °C / Inert atmosphere

7.1: ethyl trimethylsilyl ether; caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

8.1: sodium tetrahydroborate; isopropyl alcohol / dichloromethane / 0.5 h / 4 - 20 °C

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; ethyl trimethylsilyl ether; sulfuric acid; pyridinium p-toluenesulfonate; caesium carbonate; hydrazine hydrate; isopropyl alcohol; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;