1242159-03-0Relevant academic research and scientific papers
An enzyme-assisted nanoparticle crosslinking approach to enhance the mechanical strength of peptide-based supramolecular hydrogels
Li, Ying,Ding, Yin,Qin, Meng,Cao, Yi,Wang, Wei
, p. 8653 - 8655 (2013)
In this work we reported an enzyme-assisted nanoparticle crosslinking (EANC) strategy to enhance the mechanical stability of peptide-based supramolecular hydrogels by more than 3000 times. This journal is
Precursor-involved and conversion rate-controlled self-assembly of a 'super gelator' in thixotropic hydrogels for drug delivery
Ou, Caiwen,Wang, Huaimin,Yang, Zhimou,Chen, Minsheng
, p. 1781 - 1787 (2012)
Enzymatic hydrogelation is a totally different process to the heating-cooling gelation process, in which the precursors of the gelators can be involved during the formation of self-assembled structures. Using thixotropic hydrogels formed by a super gelator as our studied system, we demonstrated that the enzyme concentration/conversion rate of enzymatic reaction had a strong influence on the morphology of resulting self-assembled nanostructures and the property of resulting hydrogels. The principle demonstrated in this study not only helps to understand and elucidate the phenomenon of self-assembly triggered by enzymes in biological systems, but also offers a unique methodology to control the morphology of self-assembled structures for specific applications such as controlled drug release.
A peptide-based nanofibrous hydrogel as a promising DNA nanovector for optimizing the efficacy of HIV vaccine
Tian, Yue,Wang, Huaimin,Liu, Ye,Mao, Lina,Chen, Wenwen,Zhu, Zhening,Liu, Wenwen,Zheng, Wenfu,Zhao, Yuyun,Kong, Deling,Yang, Zhimou,Zhang, Wei,Shao, Yiming,Jiang, Xingyu
, p. 1439 - 1445 (2014/04/03)
This report shows that a nanovector composed of peptide-based nanofibrous hydrogel can condense DNA to result in strong immune responses against HIV. This nanovector can strongly activate both humoral and cellular immune responses to a balanced level rarely reported in previous studies, which is crucial for HIV prevention and therapy. In addition, this nanovector shows good biosafety in vitro and in vivo. Detailed characterizations show that the nanofibrous structure of the hydrogel is critical for the dramatically improved immune responses compared to existing materials. This peptide-based nanofibrous hydrogel shows great potential for efficacious HIV DNA vaccines and can be potentially used for delivering other vaccines and drugs.
Phenothiazine as an aromatic capping group to construct a short peptide-based 'super gelator'
Ou, Caiwen,Zhang, Jianwu,Zhang, Xiaoli,Yang, Zhimou,Chen, Minsheng
supporting information, p. 1853 - 1855 (2013/03/14)
We report a 'super-gelator' of a short peptide capped with phenothiazine acetic acid.
