1242167-47-0Relevant articles and documents
Total synthesis of (±)-bruguierol A via an intramolecular [3+2] cycloaddition of cyclopropane 1, 1-diester
Hu, Bao,Xing, Siyang,Ren, Jun,Wang, Zhongwen
experimental part, p. 5671 - 5674 (2010/10/02)
Total synthesis of natural product (±)-bruguierol A was accomplished in 10-steps and with an overall 16.8% yield. The embedded unique 8-oxabicyclo[3.2.1]octane core skeleton in this natural product was constructed via a novel Sc(OTf)3-catalyzed intramolecular [3+2] cycloaddition of cyclopropane which was developed recently in this laboratory. This general synthetic strategy can be potentially applied to the synthesis of a broad range of structurally related natural products.